Premenstrual syndrome (PMS) affects the quality of life of millions of women. The complexity and variety of clinical presentation together with the cyclic recurrence of affective and somatic symptoms increase the difficulty in understanding and treating the disease. The precise pathophysiology of PMS is still unknown, but it is increasingly believed that, in women with PMS, the sensitive equilibrium between sex-steroids and central neurotransmitters is altered. Several studies have been carried out to understand the origin of the syndrome and to discover new ways of treatment. This review summarizes the most accepted PMS theories and treatments currently available based on the results of the best-designed trials.
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Royal Free London NHS Foundation Trust, London, UK.
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Allopregnanolone in the Pathogenesis of the Psychiatric Comorbidities of Polycystic Ovarian Syndrome.
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Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address:
Context: Polycystic ovarian syndrome (PCOS) is an endocrine disorder affecting 10-15% of women of reproductive age, with significant implications for both physical and mental health. Several recent research studies have examined the connection between PCOS and psychiatric disorders; however, the mechanism linking the two is not fully understood. Allopregnanolone is a neurosteroid that modulates GABA receptors and is naturally affected by the pathophysiology of PCOS.
View Article and Find Full Text PDFComparison of the effect of teaching coping skills and acupressure on premenstrual stress: a randomized controlled trial.
Discov Ment Health
March 2025
Department of Midwifery, Faculty of Medicine, Islamic Azad University-Sanandaj Branch, Sanandaj, Iran.
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Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
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Double stigma of menstruation and premenstrual disorders for middle eastern women.
Arch Public Health
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Mental Health Research Center, Psychosocial Health Research Institute (PHRI), Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
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