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The Relationship Between Type 2 Diabetes Mellitus and Related Thyroid Diseases.
Cureus
December 2021
Department of Family Medicine, Primary Health Care Center (PHCC) Qatar, Doha, QAT.
Diabetes and thyroid diseases are caused by endocrine dysfunction and both have been demonstrated to mutually impact each other. Variation in thyroid hormone levels, even within the normal range, can trigger the onset of type 2 diabetes mellitus (T2DM), particularly in people with prediabetes. However, the available evidence is contradictory.
View Article and Find Full Text PDFA Novel Homozygous Mutation in the Solute Carrier Family 26 Member 7 Gene Causes Thyroid Dyshormonogenesis in a Girl with Congenital Hypothyroidism.
Thyroid
December 2020
Department of Molecular Pediatric Endocrinology, Johannes Gutenberg University of Mainz, Children's Hospital, Mainz, Germany.
We investigated the genetic cause of thyroid dyshormonogenesis in a girl with congenital hypothyroidism. Genetic analysis showed that she was homozygous for a hitherto not described mutation (c.1432_1433delGT, p.
View Article and Find Full Text PDFHomozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism.
JCI Insight
October 2018
Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom (UK).
Defects in genes mediating thyroid hormone biosynthesis result in dyshormonogenic congenital hypothyroidism (CH). Here, we report homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous CH and show that goitrous hypothyroidism also occurs in Slc26a7-null mice. In both species, the gene is expressed predominantly in the thyroid gland, and loss of function is associated with impaired availability of iodine for thyroid hormone synthesis, partially corrected in mice by iodine supplementation.
View Article and Find Full Text PDFThyroid Hypoplasia in Congenital Hypothyroidism Associated with Thyroid Peroxidase Mutations.
Thyroid
July 2018
2 INSERM U1163, IMAGINE Institute, Paris, France .
Background: Primary congenital hypothyroidism (CH) affects about 1:3000 newborns worldwide and is mainly caused by defects in thyroid gland development (thyroid dysgenesis [TD]) or hormone synthesis. A genetic cause is identified in <10% of TD patients. The aim was to identify novel candidate genes in patients with TD using next-generation sequencing tools.
View Article and Find Full Text PDFPrenatal Diagnosis of Fetal Goitrous Hypothyroidism in a Euthyroid Mother: A Management Challenge.
J Ultrasound Med
November 2017
Department of Obstetrics and Gynecology, Strasbourg University Hospital, Schiltigheim, France.
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