AI Article Synopsis
- - The study investigated how theophylline affects tumor growth and blood vessel formation in a mouse model of B16F10 melanoma.
- - Theophylline showed no harm to the host and significantly reduced tumor size and blood vessel formation, with statistical significance (p < 0.001).
- - The mechanism behind theophylline's effects may involve inhibiting the growth of endothelial cells, which are crucial for new blood vessel development in tumors.
Article Abstract
The aim of this study was to determine the effect of theophylline on neovascularization and tumor regression in murine B16F10 melanoma. Theophylline had no direct toxicity to host and significantly reduced (p < 0.001) tumor volume and neovascularization in B16F10 melanoma implanted murine model. The effect of theophylline on neovascularization was observed distinctly in histologic analysis. This effect is mediated, in part by blocking endothelial cell proliferation, thereby preventing neovascularization of the tumor. Further investigations with theophylline can elucidate the exact mechanism of action which characterize neovascularization activity.
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| http://dx.doi.org/10.1089/108497802753773838 | DOI Listing |
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