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Use of ivabradine in children with junctional ectopic tachycardia after pediatric cardiac surgery; two-centre experience.
J Arrhythm
December 2024
Department of Pediatric Cardiology Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences Istanbul Turkey.
Introduction: Although amiodarone is traditionally used in the treatment of postoperative junctional ectopic tachycardia (JET), the search for new treatments is ongoing. We present our experience with ivabradine at two medical centers.
Materials And Methods: Between January 2022 and January 2023, patients who developed JET after pediatric cardiac surgery were prospectively followed up and documented.
Io's tidal response precludes a shallow magma ocean.
Nature
December 2024
Southwest Research Institute, San Antonio, Texas, USA.
Io experiences tidal deformation due to its eccentric orbit around Jupiter, which provides a primary energy source for Io's ongoing volcanic activity and infrared emission. The amount of tidal energy dissipated within Io is enormous and has been hypothesized to support the large-scale melting of Io's interior and the formation of a global subsurface magma ocean. If Io has a shallow global magma ocean, its tidal deformation would be much larger than in the case of a more rigid, mostly solid interior.
View Article and Find Full Text PDFTwo distinct populations of dark comets delineated by orbits and sizes.
Proc Natl Acad Sci U S A
December 2024
Institute for Astronomy, University of Hawaii, Honolulu, HI 96822.
Small bodies are capable of delivering essential prerequisites for the development of life, such as volatiles and organics, to the terrestrial planets. For example, empirical evidence suggests that water was delivered to the Earth by hydrated planetesimals from distant regions of the Solar System. Recently, several morphologically inactive near-Earth objects were reported to experience significant nongravitational accelerations inconsistent with radiation-based effects, and possibly explained by volatile-driven outgassing.
View Article and Find Full Text PDFDual-frequency electromagnetic sounding of a Triton ocean from a single flyby.
Philos Trans A Math Phys Eng Sci
December 2024
Applied Physics Laboratory, Johns Hopkins University, MP3-E169, 11100 Johns Hopkins Road, Laurel, MD 20723, USA.
Triton, the largest satellite of Neptune, is in a retrograde orbit and is likely a captured Kuiper Belt Object (KBO). Triton has a mean density of only 2.061 gm/cm and is therefore believed to have a 250-400 km thick hydrosphere.
View Article and Find Full Text PDFJet injection through microneedles for large volume subcutaneous delivery.
Int J Pharm
December 2024
Auckland Bioengineering Institute, the University of Auckland, Auckland, New Zealand; Department of Engineering Science, Faculty of Engineering, the University of Auckland, Auckland, New Zealand.
Subcutaneous (SC) drug delivery offers several advantages over intravenous (IV) delivery including: self-administration, improved patient experience, and reduced treatment costs. Unfortunately, each SC delivery is currently limited to ∼ 2.25 mL with IV administration required when the delivery volume exceeds this value.
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