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Large experience with a factor VIII binding assay of plasma von Willebrand factor using commercial reagents. | LitMetric

Large experience with a factor VIII binding assay of plasma von Willebrand factor using commercial reagents.

Br J Haematol

Department of Haematology, University Cardiological Hospital, Boulevard du Professeur J. Leclerq, 59037 Lille Cedex, France.

Published: June 2002

AI Article Synopsis

Article Abstract

The present diagnostic assay for type 2N von Willebrand disease (VWD) is based on the in vitro measurement of the capacity of plasma von Willebrand factor (VWF) to bind exogeneous factor VIII (VWF:FVIIIB). We report a method using only commercially available reagents that is easy to perform. This method has been validated in a cohort of 144 patients with FVIII/VWF ratios < 0.6 using a plasma control mixture representative of intermediate VWF:FVIIIB. In total, 15 patients were diagnosed with markedly decreased VWF:FVIIIB and five patients were shown to have moderately decreased VWF:FVIIIB. Specific type 2N mutations were identified in all these patients.

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Source
http://dx.doi.org/10.1046/j.1365-2141.2002.03488.xDOI Listing

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