AI Article Synopsis
- Streptonigrin and its derivative were isolated from a strain of actinomycete called Micromonospora sp. IM 2670.
- Both compounds show stronger effects in inducing cell death in neuroblastoma cells with normal p53 compared to those with a mutated p53.
- This indicates that their mechanism of action may involve a pathway reliant on the p53 protein, which is known for its role in regulating cell apoptosis.
Article Abstract
Streptonigrin (1) and its novel natural derivative 7-(1-methyl-2-oxopropyl)streptonigrin (2) were isolated from an actinomycete strain, Micromonospora sp. IM 2670. The inductions for 1 and 2 are more potent in the human neuroblastoma SH-SY5Y cells that contain wild-type p53 than in SH-SY5Y-5.6 cells that overexpress a dominant negative mutant of p53, thus suggesting that they induce apoptosis through a p53-dependent pathway.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np0104572 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the Role of a Putative Secondary Metabolite Biosynthesis Pathway in Pathogenesis Using a Tadpole Model.
Microorganisms
May 2024
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
is an emerging human pathogen that has a high rate of incidence in immunocompromised individuals. We have found a putative secondary metabolite pathway within , which may be a key factor in its pathogenesis. This novel pathway is encoded in a gene cluster spanning MAB_0284c to 0305 and is related to pathways, producing the secondary metabolites streptonigrin and nybomycin.
View Article and Find Full Text PDFDiscovery of novel 1H-benzo[d]imidazole-4,7-dione based transglutaminase 2 inhibitors as p53 stabilizing anticancer agents in renal cell carcinoma.
Bioorg Chem
February 2024
School of Life Sciences, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea. Electronic address:
Overexpression of transglutaminase 2 (TGase 2; TG2) has been implicated in the progression of renal cell carcinoma (RCC) through the inactivation of p53 by forming a protein complex. Because most p53 in RCC has no mutations, apoptosis can be increased by inhibiting the binding between TG2 and p53 to increase the stability of p53. In the present study, a novel TG2 inhibitor was discovered by investigating the structure of 1H-benzo[d]imidazole-4,7-dione as a simpler chemotype based on the amino-1,4-benzoquinone moiety of streptonigrin, a previously reported inhibitor.
View Article and Find Full Text PDFCharacterization of ribonucleotide reductases of emerging pathogens and and streptonigrin as their inhibitor: a computational study.
J Biomol Struct Dyn
December 2022
Department of Oral and Maxillofacial Surgery, Dhaka Dental College, Dhaka, Bangladesh.
Antibiotic resistance is a global concern. Two members of the bacterial genus namely, and have raised much concern in recent years because of their resistance to multiple commonly used antibiotics. Identification of multidrug resistant and pan-drug resistant bacteria has propelled the search for new antibiotics that can act on unconventional targets.
View Article and Find Full Text PDFA novel streptonigrin type alkaloid from the CGMCC 4.1223 mutant Δ.
Nat Prod Res
July 2022
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory on Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Streptonigrin (STN) is a highly functionalized aminoquinone alkaloid with broad and potent antitumor activities. Previously, the biosynthetic gene cluster of STN was identified in CGMCC 4.1223, revealing an α/β-hydrolase (StnA) and a methyltransferase (StnQ2).
View Article and Find Full Text PDFA Novel Heme Transporter from the Energy Coupling Factor Family Is Vital for Group A Streptococcus Colonization and Infections.
J Bacteriol
June 2020
Department of Biology, Georgia State University, Atlanta, Georgia, USA
Group A streptococcus (GAS) produces millions of infections worldwide, including mild mucosal infections, postinfection sequelae, and life-threatening invasive diseases. During infection, GAS readily acquires nutritional iron from host heme and hemoproteins. Here, we identified a new heme importer, named SiaFGH, and investigated its role in GAS pathophysiology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!