Twelve new briarane diterpenes, designated milolides (1-12), and one known diterpene, 9-deacetylstylatulide lactone (13), were isolated from the Micronesian octocoral Briareum stechei collected at Yap, Federated States of Micronesia. Their structures were determined from spectral data.
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http://dx.doi.org/10.1021/np010640v | DOI Listing |
Mar Drugs
February 2023
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
The chemical screening of a cultured soft coral, , led to the isolation of eight natural, briarane-related diterpenoids, including three unreported metabolites, briavioids E-G (-), and five known briaranes, briacavatolides B () and C (), briaexcavatin L (), briaexcavatolide U () and briarenol K (). The structures of briaranes - were established using spectroscopic methods. The absolute configuration of briavioid A (), obtained in a previous study, was reported for the first time in this study by a single-crystal X-ray diffraction analysis using a copper radiation source.
View Article and Find Full Text PDFChem Pharm Bull (Tokyo)
February 2023
Department of Marine Biotechnology and Resources, National Sun Yat-sen University.
A formerly unpublicized briarane diterpenoid, briastecholide M (1), and its established analogue, brianodin B (2), were purified from Briareum stechei, an octocoral collected from Okinawan waters. Using spectroscopic methods, the structure of 1 was established. Functional study showed that 1 can reducing the release of inducible nitric oxide synthase (iNOS) but enhancing cyclooxygenase-2 (COX-2) protein expression.
View Article and Find Full Text PDFPharmaceuticals (Basel)
July 2022
Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Excavatolide C (EXCC) is a bioactive compound derived from the gorgonian octocoral , and its anticancer effects are rarely addressed, particularly for bladder cancer. This investigation aimed to explore the potential impacts of EXCC on inhibiting the proliferation of three kinds of bladder cancer cells (5637, BFTC905, and T24). EXCC inhibits bladder cancer cell proliferation based on 48 h ATP assay.
View Article and Find Full Text PDFMolecules
November 2021
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
A known polyoxygenated briarane, briaexcavatolide P (), was isolated from a Formosan octocoral . Moreover, the same species , collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B () and C () as well as a known analogue, briarenol R (). The structures of - were established using spectroscopic methods.
View Article and Find Full Text PDFMar Drugs
February 2021
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
Chemical investigation of the octocoral , collected in the Ie Island, Okinawa, Japan, resulted in the isolation of a new briarane-type diterpenoid, briastecholide A (), as well as the previously reported metabolites, solenolide C () and briarenolide S (). The structures of briaranes - were characterized through spectroscopic analysis, and the absolute configuration of was corroborated by a single-crystal X-ray diffraction analysis. Briarane exhibited bioactivity against the protein expression of inducible nitric oxide synthase (iNOS).
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