R. A. Fisher's Fundamental Theorem of Natural Selection states that the rate of increase in the mean fitness of a population ascribable to gene-frequency changes is exactly equal to the additive genetic variance in fitness. It has been widely misunderstood, though clarification has gradually come about particularly through the work of G. R. Price, W. J. Ewens, and S. Lessard. Building on their interpretations we here explain the approach adopted by Fisher (1941), devising a figure as an aid to understanding this important paper.
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http://dx.doi.org/10.1006/tpbi.2002.1570 | DOI Listing |
PLoS One
March 2025
Instituto de Investigación en Zoonosis (CIZ), Universidad Central del Ecuador, Quito, Ecuador.
Anaplasmosis is a tick-borne disease (TBDs) caused by Anaplasma spp. In areas where TBDs are endemic, it is crucial to consider the animals' immunological status in relation to these diseases. The true prevalence of bovine anaplasmosis, the percentage of animals with protective antibodies against this TBD, and the diagnostic characteristics of three tests (multiplex polymerase chain reaction (mPCR), competitive-inhibition enzyme-linked immunosorbent assay (cELISA), and blood smear (BS)) were estimated using a Bayesian approach.
View Article and Find Full Text PDFbioRxiv
February 2025
Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
When it comes to understanding the role that population structure plays in shaping rates of evolution, it is commonly accepted that interference between evolutionary innovations is more prevalent in structured populations compared to well-mixed, and that population structure reduces the rate of evolution, while simultaneously promoting maintenance of genetic variation. Prior models usually represent population structure using two or more connected demes or lattices with periodic boundary conditions. Fundamentally, the observed spatial evolutionary slow-down is rooted in the fact that these types of structures increase the time it takes for a selective sweep and therefore, increase the probability that multiple beneficial mutations will coexist and interfere.
View Article and Find Full Text PDFBMC Infect Dis
March 2025
Research Team for Transmission Dynamics of Infectious Diseases, National Institute for Mathematical Sciences, 70, Yuseong-daero 1689 beon-gil, Yuseong-gu, 34047, Daejeon, Republic of Korea.
Background: Understanding social contact patterns is fundamental to the study of infectious disease transmission. However, in South Korea, detailed social contact data have not been publicly available. While global research on social contact patterns has expanded, there remains a critical need for more context-specific data in South Korea.
View Article and Find Full Text PDFFront Immunol
February 2025
National Cytometry Platform, Translational Medicine Operations Hub, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Gating is a fundamental and essential process in cytometry data analysis since it defines cell types of interest. Currently, there is no universally accepted method for representing and sharing gating strategies among software, publications, and repositories. I propose using the Prime Population system combined with a modified version of Gödel Numbers to identify any gating strategy uniquely.
View Article and Find Full Text PDFPhys Rev Lett
February 2025
ICFO-Institut de Ciències Fotòniques, University of Bristol, H. H. Wills Physics Laboratory, Tyndall Avenue, Bristol BS8 1TL, United Kingdom and , The Barcelona Institute of Science and Technology, 08860 Castelldefels, Spain.
Energy transfer and information transmission are two fundamental aspects of nature. They are seemingly unrelated, while recent findings suggest that a deep connection between them is to be discovered. This amounts to asking: Can we phrase the processes of transmitting classical bits equivalently as specific energy-transmitting tasks, thereby uncovering foundational links between them? We answer this question positively by showing that, for a broad class of classical communication tasks, a quantum dynamics' ability to transmit n bits of classical information is equivalent to its ability to transmit n units of energy in a thermodynamic task.
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