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Predicting in vivo concentrations of dietary hop phytoestrogens by physiologically based kinetic modeling.
Food Chem Toxicol
January 2025
Department of Health Sciences and Technology, ETH Zurich, Switzerland. Electronic address:
Hop extracts containing prenylated polyphenols such as 8-prenylnaringenin (8-PN) and its precursor isoxanthohumol (iXN) are popular among women seeking natural alternatives to hormone therapy for postmenopausal symptoms. Due to structural similarities with estrogens, these compounds act as estrogen receptor agonists. Especially 8-PN, described as the most potent phytoestrogen known to date, poses a potential risk for endocrine disruption.
View Article and Find Full Text PDFTreatment of rapid recurrence of severe steatosis with combined GLP-1 agonist and growth hormone therapy in a pediatric patient transplanted for metabolic dysfunction-associated steatohepatitis cirrhosis in the setting of hypopituitarism.
Am J Transplant
January 2025
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
The association between hypopituitarism and metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized, although data about therapies targeting recurrence post-transplant is limited. An 8-year-old with hypopituitarism-associated MASLD underwent a liver transplant due to rapid progression of metabolic dysfunction-associated steatohepatitis (MASH). Hepatosteatosis recurred within weeks.
View Article and Find Full Text PDFNoncanonical RGS14 structural determinants control hormone-sensitive NPT2A-mediated phosphate transport.
Biochem J
January 2025
University of Pittsburgh School of Medicine, Pittsburgh, United States.
The sodium phosphate cotransporter-2A (NPT2A) mediates basal and parathyroid hormone (PTH)- and fibroblast growth factor-23 (FGF23)-regulated phosphate transport in proximal tubule cells of the kidney. Both basal and hormone-sensitive transport require sodium hydrogen exchanger regulatory factor-1 (NHERF1), a scaffold protein with tandem PDZ domains, PDZ1 and PDZ2. NPT2A binds to PDZ1.
View Article and Find Full Text PDFFactors influencing endometrial receptivity in women with recurrent implantation failure.
BMC Womens Health
January 2025
OVIklinika Infertility Center, Połczyńska 31, Warsaw, 01-377, Poland.
Background: Embryo implantation involves two key elements: a good quality embryo and receptive endometrium. Endometrial receptivity abnormalities are known as one of the possible causes of recurrent implantation failure (RIF), especially when the embryo is euploid. This study was aimed to evaluate the impact of age and other clinical factors on endometrial receptivity in women with RIF.
View Article and Find Full Text PDFDevelopment of HRP-assisted rGO-FET biosensors for high-precision measurement of serological steroid hormones.
Anal Chim Acta
January 2025
Department of Medical Biotechnology, College of Life Science and Biotechnology, Dongguk University, Seoul, 04620, Republic of Korea. Electronic address:
Background: Sarcopenia, which is associated with many pathways and molecular mechanisms, not only deteriorates the quality of life in old age but is also linked to various diseases. The ratio between cortisol and dehydroepiandrosterone sulfate (DHEAS) was utilized as a candidate method to diagnose sarcopenia. The hormones can fluctuate in concentration throughout the day, so monitoring the ratio between the two hormones is necessary.
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