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A New and Safe Delivery of Sildenafil Citrate Co-Evaporate Loaded Emulgels for the Cure of Certain Male Sexual Dysfunctions.
AAPS PharmSciTech
January 2025
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
The present work focuses on the production of sildenafil co-evaporates loaded emulgels as topical dosage forms for the treatment of premature ejaculation and erectile dysfunction. Topical administration of sildenafil citrate (SILD) co-evaporates is expected to improve the bioavailability profile of the drug and to avoid the severe side effects accompanying the traditional SILD dosage forms, especially for prohibited cardiovascular cases. Firstly, the solubility of SILD was improved via solid dispersion via co-evaporation technique using PEG-5KDa and PVP-K90 as hydrophilic carriers.
View Article and Find Full Text PDFThe "prostate-pelvic syndrome" theory used in patients with type-III prostatitis and its correlation with prostate volume.
BMC Urol
January 2025
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, 230022, China.
Background: Type-III prostatitis is the most common prostate disease in adult males below 40 years old. The actual operation of its diagnosis process is cumbersome. Recently, a group of top Chinese urologists have proposed the theory of "prostate-pelvic syndrome (PPS)" and suggested using it to replace the traditional term for type-III prostatitis.
View Article and Find Full Text PDFRobotic Waterjet Resection for Men with Prostate Cancer Suffering from Lower Urinary Tract Symptoms.
Urology
January 2025
S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Objectives: To evaluate the impact of Aquablation on circulating tumor cells (CTCs) in men with localized prostate cancer.
Methods: This prospective study included subjects with biopsy-positive mpMRI visible lesions (PIRADS ≥ 3) who underwent Aquablation. Ten ml blood samples were collected before, during and after the procedure to measure CTC counts using an immunofluorescence assay.
Impact of bladder management methods and other factors on sexual activity in women with chronic spinal cord injury/disease.
Sex Med
December 2024
Swiss Paraplegic Research, Neuro-Urology, Nottwil, 6207, Switzerland.
Background: Spinal cord injury/disease (SCI/D) profoundly affects both sexuality and urinary function. Catheterization is often necessary to manage bladder voiding and it can interfere with sexual activity.
Aim: We aim to investigate the effect of the bladder evacuation method on sexual activity in women with chronic SCI/D.
Women sexual dysfunction in the postpartum period: concept analysis.
Rev Gaucha Enferm
January 2025
Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brasil.
Objective: To analyze the concept of sexual dysfunction in postpartum women and identify their essential attributes, antecedents, and effects.
Method: Concept analysis based on a framework by Walker and Avant, elaborated in eight stages, which were: concept selection; identification of the use of the concept; determination of essential attributes; construction of the model case; additional case; identification of antecedents and effects; and definition of empirical references. Furthermore, an integrative review was carried out simultaneously, with a view to supporting the analysis of the concept.
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