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Comprehensive analysis of flower extracts: phytochemical composition and toxicity in zebrafish embryos.
Nat Prod Res
January 2025
Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil.
(L.) R. Br.
View Article and Find Full Text PDFAntibacterial activity of 1 % Roselle flower nano-emulsion extract (Hibiscus sabdariffa) against peri-implantitis-related bacteria on orthodontic mini-implants: An in vitro study.
J Oral Biol Craniofac Res
January 2025
Orthodontic Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
Objective: The orthodontic mini-implant (OMI) failure often occurs due to the accumulation of peri-implantitis bacteria surrounding it, which results in a stable, resistant form of absolute skeletal anchorage during orthodontic treatment. Administering doxycycline may be the solution, but long-term side effects result in antibiotic resistance. Roselle flowers (Hibiscus sabdariffa) possess beneficial active phytochemical substances, which may have potential as an OMI peri-implantitis alternative therapy.
View Article and Find Full Text PDFMolecular docking-guided in-depth investigation of the biological activities and phytochemical and mineral profiles of endemic Phlomis capitata.
J Sci Food Agric
January 2025
Bee and Natural Products R&D and P&D Application and Research Center, Bingöl University, Bingöl, Turkey.
Background: Phlomis capitata is an endemic species of flowering aromatic and medicinal plant in the family Lamiaceae, native to regions of the Mediterranean and nearby areas. Understanding the chemical compounds present in P. capitata can reveal potential medicinal properties.
View Article and Find Full Text PDFIsolation and spectroscopic characterization of anticancer phytochemicals from : a combined experimental and theoretical investigation using ADMET analysis and in silico molecular docking simulation against key cancer targets.
Nat Prod Res
January 2025
Department of Chemistry, Islamic University of Science and Technology, Awantipora, JK, India.
, a high-altitude medicinal herb, possesses diverse therapeutic properties. This study conducted a comprehensive phytochemical analysis of the whole plant, leading to the isolation of 15 secondary metabolites (1-15) across various classes: flavonoids (), triterpenoids (, ), sesquiterpenoid lactones (, ) and furanocoumarins (, ) along with three steroids (). These compounds were characterized using NMR (HNMR,C NMR, 2D NMR), IR, HRMS and UV-VIS.
View Article and Find Full Text PDFIn-vitro susceptibility of pathogenic and intermediate Leptospira species towards antibiotics and herb extracts.
Trop Biomed
December 2024
Resource Biotechnology Programme, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300, Kota Samarahan, Sarawak, Malaysia.
Leptospirosis is a severe and potentially fatal re-emerging zoonotic and waterborne disease caused by pathogenic and intermediate species of Leptospira. Given the high global rates of morbidity and mortality associated with this disease, there is an urgent need to explore alternative therapeutic agents to enhance treatment options. This study investigates the anti-leptospiral efficacy of several common antibiotics-penicillin G, doxycycline, ampicillin, amoxicillin, cefotaxime, chloramphenicol, and erythromycin, as well as extracts from local herbs, Hydnophytum formicarum Jack and Boesenbergia stenophylla, against pathogenic and intermediate Leptospira strains.
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