AI Article Synopsis
- The study aimed to compare the production of IL-6 and MCP-1 in patients with and without peritonitis, focusing on how their peritoneum reacts to infection.
- In patients with peritonitis, spontaneous IL-6 production was higher, while LPS-stimulated MCP-1 production was lower compared to uninfected patients.
- Overall, both IL-6 and MCP-1 were found in higher serum concentrations in infected patients, with the most critical connections noted in those who did not survive.
Article Abstract
The aim of the study was to compare peritoneal and systemic production of interleukin 6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in uninfected patients and in patients with peritonitis. Peritoneum was excised at laparotomy for acute peritonitis (n = 22) or noninfectious reasons (n = 61), and was incubated with or without lipopolysaccharide (LPS). Mediator concentrations in the culture-supernatants, in the patients' serum, and in plasmasupernatants of LPS-stimulated whole blood were related to outcome. Spontaneous production of IL-6 by the peritoneum was increased in infected patients compared with uninfected patients. In contrast to IL-6, LPS-stimulated production of MCP-1 was significantly less in infected patients. Serum concentrations of both mediators were higher in infected patients and the highest concentrations of MCP-1 were in patients who died. LPS-stimulated production of IL-6 in whole blood was least, whereas that of MCP-1 was greatest in infected patients who died. These contrasting results for local and systemic production of mediators illustrate the compartmentalized immune response to intra-abdominal infection.
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| http://dx.doi.org/10.1097/00024382-200205000-00003 | DOI Listing |
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