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Detailed analysis of cystic lesions in patients after open fetal repair and postnatal myelomeningocele closure.
Childs Nerv Syst
January 2025
Division of Neurosurgery, Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Purpose: We sought to evaluate the incidence, natural history, and management of cystic spinal lesions following myelomeningocele/myeloschisis closure.
Methods: We performed a single-center retrospective review of all patients who underwent myelomeningocele/myeloschisis closure from 2013 to 2018 with follow-up to 5 years old.
Results: We analyzed 100 fetal repairs and 81 postnatal closures from 305 total surgeries.
DEK::AFF2 fusion-associated middle ear non-keratinizing squamous cell carcinoma: A case report.
World J Clin Oncol
December 2024
Department of Pathology, Peking University People's Hospital, Beijing 100044, China.
Background: Primary squamous cell carcinoma (SCC) of the middle ear is rare, with non-keratinizing basaloid types being exceptionally uncommon. Distinguishing these cancers, often caused by viral factors (, human papillomavirus or Epstein-Barr virus), or specific genetic alterations (, bromodomain-containing protein 4-nuclear protein in or gene fused with FLI chromosomal rearrangement), from other cranial conditions, is difficult. The recently identified DEK::AFF2 non-keratinizing SCC (NKSCC) is a novel subtype, fitting the World Health Organization classification of head and neck neoplasms.
View Article and Find Full Text PDFSymptomatic Progression, Recurrence, and Long-Term Follow-Up of Patients With Intracranial Epidermoid Cysts.
Neurosurgery
December 2024
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Background And Objectives: Intracranial epidermoid cysts are rare, slow-growing but highly recurrent tumors with incompletely understood symptoms, progression, complications, and outcomes. The aim of the study was to characterize the symptomatology, surgical management, and long-term outcomes of these tumors.
Methods: This single-center retrospective analysis identified patients with pathologically confirmed intracranial epidermoid cysts from 1989 to 2023.
The importance of timing: evaluating the optimal age for surgical intervention in asymptomatic dermal sinus tracts.
J Neurosurg Pediatr
November 2024
1Department of Neurosurgery, Children's National Medical Center.
Article Synopsis
- Dermal sinus tracts (DSTs) are rare congenital lesions that pose risks of infection and neurological issues due to their connection between the skin and spinal cord, making surgical intervention recommended, though the timing for surgery in asymptomatic cases is uncertain.
- A retrospective review from 1998 to 2022 studied 52 patients who underwent DST excision and detethering, excluding those with pre-existing complications.
- Results indicated a median surgery age of 7 months, with complications in 8% of cases, and younger age at surgery was linked to higher risks of postoperative problems and continued neurological issues.
Ossified spinal epidermoid cyst: A systematic review and case report.
Heliyon
September 2024
Achieve Brain & Spine, Santa Monica, CA, USA.
Background: Epidermoid cysts (ECs) are rare, benign lesions which comprise less than 1 % of all spinal tumors. Calcification of spinal ECs is rare, and EC ossification within the lumbar spine has never been documented. We report the only known congenital lumbar epidermoid tumor with ossification and a literature review of intradural lumbar ECs.
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