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| http://dx.doi.org/10.1093/genetics/161.1.1 | DOI Listing |
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lncRNA read-through regulates the BX-C insulator .
Elife
August 2023
Department of Molecular Biology, Princeton University, Princeton, United States.
Though long non-coding RNAs (lncRNAs) represent a substantial fraction of the Pol II transcripts in multicellular animals, only a few have known functions. Here we report that the blocking activity of the Bithorax complex (BX-C) boundary is segmentally regulated by its own lncRNA. The boundary is located between the () gene and the regulatory domain, which is responsible for regulating expression in parasegment PS6/segment A1.
View Article and Find Full Text PDFRedundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila.
Development
October 2021
Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia.
The Abdominal-B (Abd-B) gene belongs to the bithorax complex and its expression is controlled by four regulatory domains, iab-5, iab-6, iab-7 and iab-8, each of which is thought to be responsible for directing the expression of Abd-B in one of the abdominal segments from A5 to A8. A variety of experiments have supported the idea that BX-C regulatory domains are functionally autonomous and that each domain is both necessary and sufficient to orchestrate the development of the segment they specify. Unexpectedly, we discovered that this model does not always hold.
View Article and Find Full Text PDFHox genes, clusters and collinearity.
Int J Dev Biol
May 2019
Stowers Institute for Medical Research, Kansas City, Missouri, USA.
This year marks the 40th anniversary of the discovery by Ed Lewis of the property of collinearity in the bithorax gene complex in Drosophila. This landmark work illustrated the need to understand regulatory mechanisms that coordinate expression of homeotic gene clusters. Through the efforts of many groups, investigation of the Hox gene family has generated many fundamental findings on the roles and regulation of this conserved gene family in development, disease and evolution.
View Article and Find Full Text PDFDifferent Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex.
Genetics
February 2017
Department of Molecular Biology, Princeton University, New Jersey 08544
Chromatin boundary elements subdivide chromosomes in multicellular organisms into physically independent domains. In addition to this architectural function, these elements also play a critical role in gene regulation. Here we investigated the evolution of a Drosophila Bithorax complex boundary element called Fab-7, which is required for the proper parasegment specific expression of the homeotic Abd-B gene.
View Article and Find Full Text PDFThe open for business model of the bithorax complex in Drosophila.
Chromosoma
September 2015
Department of Genetics and Evolution, University of Geneva, 30 quai E. Ansermet, 1211, Geneva-4, Switzerland.
After nearly 30 years of effort, Ed Lewis published his 1978 landmark paper in which he described the analysis of a series of mutations that affect the identity of the segments that form along the anterior-posterior (AP) axis of the fly (Lewis 1978). The mutations behaved in a non-canonical fashion in complementation tests, forming what Ed Lewis called a "pseudo-allelic" series. Because of this, he never thought that the mutations represented segment-specific genes.
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