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Immunotherapy-Resistant Neuropathic Pain and Fatigue Predict Quality-of-Life in Contactin-Associated Protein-Like 2 Antibody Disease.
Ann Neurol
January 2025
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
The long-term clinical outcomes and associated prognostic factors in contactin-associated protein-like 2 (CASPR2)-antibody diseases are unknown. A total of 75 participants with CASPR2 antibodies were longitudinally assessed for disability, quality-of-life, and chronic pain. Although most symptoms improved within 6 months of treatment, neuropathic pain and fatigue were the most immunotherapy refractory, and persisted for up to 6 years.
View Article and Find Full Text PDFThe widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes.
Nat Commun
January 2025
Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Bacterial artificial chromosome transgenic models, including most Cre-recombinases, enable potent interrogation of gene function in vivo but require rigorous validation as limitations emerge. Due to its high relevance to metabolic studies, we perform comprehensive analysis of the Ucp1-Cre line which is widely used for brown fat research. Hemizygotes exhibit major brown and white fat transcriptomic dysregulation, indicating potential altered tissue function.
View Article and Find Full Text PDFBuilding Family Medicine Research Through Community Engagement: Leveraging Federal Awards to Develop Infrastructure.
J Am Board Fam Med
January 2025
From the Department of Family Medicine and Community Health, Rutgers Health, 303 George Street, Matrix Plaza 1, Room 614, New Brunswick, NJ (AFT, JMF, MEJ, MP, MFC, EJ, SVH); New Jersey Alliance for Clinical and Translational Science, New Brunswick, NJ (AFT, DH, MEJ, SVH); Office of University-Community Partnerships, Rutgers University, Newark, NJ (DH); Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (MEJ); Rutgers Robert Wood Johnson Medical School, Rutgers Institute for Translational Medicine and Science, New Brunswick, NJ, USA (SVH).
Many academic departments and programs struggle with the challenge of how to begin a meaningful research program. A useful place to start is with the work they already are doing in communities. Using work in practices and other clinical venues as a springboard can build helpful relationships that can catalyze research and build infrastructure that matters to family medicine clinicians, researchers, and the communities they serve.
View Article and Find Full Text PDFSynaptic protein expression in bipolar disorder patient-derived neurons implicates PSD-95 as a marker of lithium response.
Neuropharmacology
January 2025
Department of Psychiatry and Center for Circadian Biology, University of California San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA. Electronic address:
Bipolar disorder (BD) is a severe mental illness characterized by recurrent episodes of depression and mania. Lithium is the gold standard pharmacotherapy for BD, but outcomes are variable, and the relevant therapeutic mechanisms underlying successful treatment response remain uncertain. To identify synaptic markers of BD and lithium response, we measured the effects of lithium on induced pluripotent stem cell-derived neurons from BD patients and controls.
View Article and Find Full Text PDFThis Journal of Biocommunication Gallery features a selection of the Best of Show Winners from 10 years of BioImages. We have selected the winning entries of the last decade to showcase the variety, breadth and depth of work in these award-winning images. BioImages is the BioCommunications Association's annual visual media competition that showcases the finest still, graphics and motion media work in the life sciences and medicine.
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