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High-throughput and sustainable B vitamins analysis in nutritional supplements, vegetables, and fruits via 2D carbon microfiber fractionation system coupled with mass spectrometry.
Talanta
January 2025
College of Pharmacy, Yanbian University, Park Road 977, Yanji, 133002, Jilin Province, PR China; Department of Chemistry, Interdisciplinary Program of Biological Functional Molecules, College of Integration Science, Yanbian University, Park Road 977, Yanji, 133002, Jilin Province, PR China. Electronic address:
B vitamins are essential for energy metabolism, nervous health, blood production, and the immune system. Their quantification in nutritional supplements and food is mandatory to manage a correct daily intake and dosage. In this study, a fast and sustainable method for the analysis of 8 B vitamins (VB, VB, VB, nicotinamide, VB, VB, VB, VB) in real samples using a 2D-carbon microfiber fractionation system combined with a triple quadrupole mass spectrometer (2DμCFs-QqQ-MS/MS) is presented.
View Article and Find Full Text PDFSpatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity.
Cell Biosci
January 2025
Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China.
Background: Intratumoral heterogeneity emerges from accumulating genetic and epigenetic changes during tumorigenesis, which may contribute to therapeutic failure and drug resistance. However, the lack of a quick and convenient approach to determine the intratumoral epigenetic heterogeneity (eITH) limit the application of eITH in clinical settings. Here, we aimed to develop a tool that can evaluate the eITH using the DNA methylation profiles from bulk tumors.
View Article and Find Full Text PDF[Using Therapeutic Play to Increase the Oral Administration Adherence Rate of Preschool Pediatric Inpatients].
Hu Li Za Zhi
February 2025
Department of Nursing, MacKay Memorial Hospital, Taiwan, ROC.
Background & Problems: Oral administration is the most common mode of medical treatment for pediatric patients. Although over 98% of the patients in the targeted pediatric unit require oral medication, the oral administration adherence rate in 2022 was 43.9%.
View Article and Find Full Text PDFRapid screening of pottery lipid residue profile via comprehensive two-dimensional gas chromatography.
Anal Chim Acta
February 2025
Department of Archaeology and Anthropology, School of Humanities, University of Chinese Academy of Sciences, 100049, Beijing, China. Electronic address:
Background: Pottery lipid residue analysis has been extensively practiced worldwide as an important part of archaeometry studies, but in some cases, the complexity of archaeological residue cannot be fully revealed by one-dimensional gas chromatography (1D GC) separation. Although the development of comprehensive two-dimensional gas chromatography (GCxGC) has offered another way to achieve better separation and higher resolution, GCxGC separation has rarely been applied to pottery residue analysis. Clearly, GCxGC separation needs to be explored to examine and scrutinize the complexity of pottery lipid residue profile as well as rapid data treatment workflow.
View Article and Find Full Text PDFUltrasound-guided trigger thumb release.
Hand Surg Rehabil
January 2025
Orthopedic Surgery Department, CHU Caremeaux, Nîmes, France.
The purpose of this study was to evaluate the results of a novel retrograde ultrasound-guided A1 pulley release technique for the treatment of trigger thumb. We conducted a retrospective, single-center study of 42 patients who underwent ultrasound-guided A1 pulley release for clinically diagnosed trigger thumb between September 2022 and December 2023. All cases were graded according to the Green classification of trigger finger severity.
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