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Disruption of nontuberculous mycobacteria biofilms induces a highly vulnerable to antibiotic killing phenotype.
Biofilm
December 2023
Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
Objectives: Structural or mucus hypersecretory pulmonary diseases such as cystic fibrosis (CF), wherein viscous mucus accumulates and clearance functions are impaired, predispose people to lung infection by inhaled bacteria that form biofilm aggregates. Nontuberculous mycobacteria (NTM), primarily and are the growing cause of these lung infections and are extremely challenging to treat due to antibiotic recalcitrance. Better therapeutic approaches are urgently needed.
View Article and Find Full Text PDFCystic Hypersecretory Carcinoma of the Breast: A Rare Case Report with Review of Literature and Emphasis on Differential Diagnosis.
South Asian J Cancer
July 2023
Department of Oncopathology, Gujarat Cancer Research Institute, Ahmedabad, Gujarat.
Karthik DhandapanCystic hypersecretory carcinoma (CHC) is a rare subset of in-situ breast carcinoma with or without associated invasive carcinoma. It is part of a spectrum of cystic hypersecretory lesions that includes cystic hypersecretory hyperplasia (CHH), CHH with atypia, CHC in situ, and CHC with invasion. Only 20 cases of CHC with invasion have been reported so far.
View Article and Find Full Text PDFCystic hypersecretory lesions - invasive breast carcinoma-spectrum of a rare tumour.
Autops Case Rep
November 2023
Unipath Speciality Laboratory Limited, Department of Histopathology and Cytopathology, Kolkata, India.
Invasive Cystic Hypersecretory Ductal Carcinoma of Breast: Challenges in Diagnosis and Management.
Case Rep Oncol
November 2023
Department of Pathology, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.
Cystic hypersecretory lesions of the breast are a spectrum of conditions ranging from cystic hypersecretory hyperplasia with atypia and invasive cystic hypersecretory carcinoma (CHC). It is a subtype of ductal carcinoma of the breast. The tumour is very infrequent and hence, extensive literature is limited.
View Article and Find Full Text PDFAtypical cystic hypersecretory lesions of the breast commonly harbour TP53 alterations.
Histopathology
December 2023
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Aims: Cystic hypersecretory lesions are rare and include atypical cystic hypersecretory hyperplasia (A-CHH) and cystic hypersecretory carcinoma in situ (CHC-IS). Despite detailed morphological descriptions, little is known about the genetic landscape of these lesions.
Methods And Results: We identified four A-CHH and three CHC-IS from 2010 to 2022.
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