The investigation of the effects of glycyrrhetic acid on spontaneous secretion of transmitter from neurotermination of the frog neuromuscular synapses showed that this substance, unlike glycyrrhizic acid, increased the frequency and amplitude of m. e. p. p. in a dose-dependent manner. The effect of glycyrrhetic acid is observed in calcium-free solution which may indicate ability of glycyrrhetic acid to mobilize calcium from inner cell pools. The effects of glycyrrhetic acid, in particular increasing the frequency of the m. e. p. p., testify that glycyrrhetic acid acts on the level of presynaptic membrane.
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