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Letter to the Editor - Untargeted metabolomics and mendelian randomization analysis identify alpha-linolenic acid and linoleic acid as novel biomarkers of perioperative neurocognitive dysfunction.
Clin Nutr
January 2025
The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China. Electronic address:
Multi-omics and network pharmacology approaches reveal Gui-Ling-Ji alleviates oligoasthenoteratozoospermia by regulating arachidonic acid pathway.
Phytomedicine
December 2024
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.; School of Pharmacy, Naval Medical University, Shanghai 200433, China.; School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.; School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.. Electronic address:
Background: Gui-Ling-Ji (GLJ) described in the ancient medical book 'Yunji Qijian' is a traditional Chinese medicine formula used to improve male fertility. It is now available for the treatment of oligoasthenoteratozoospermia (OAT). However, the active ingredients and mechanism of GLJ are not clear.
View Article and Find Full Text PDFMeasurement of nitro-oleic acid and nitro-linoleic acid in plasma by GC-MS/MS and LC-MS/MS in health and disease: The significance of the internal standard.
J Chromatogr B Analyt Technol Biomed Life Sci
April 2023
Hannover Medical School, Institute of Toxicology, Core Unit Proteomics, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address:
Serum Metabolomics Based on GC-MS Reveals the Antipyretic Mechanism of Ellagic Acid in a Rat Model.
Metabolites
May 2022
Guangxi Engineering Research Center of Ethnic Medicine Resources and Application, Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China.
Ellagic acid (EA) is a polyphenol dilactone that has been reported to have antipyretic, anti-inflammatory, anti-tumor, and antioxidant activities, but the mechanism of action has not been reported. In this study, serum metabolomics was used to explore the mechanism of EA on rat fever induced by beer yeast, and to screen out marker metabolites to provide a reference for the antipyretic effect of EA. The acute fever model of male Sprague Dawley rats involved subcutaneous injection with 20% aqueous suspension of yeast (15 mL/kg) in their back.
View Article and Find Full Text PDFABTL0812 enhances antitumor effect of paclitaxel and reverts chemoresistance in triple-negative breast cancer models.
Cancer Commun (Lond)
June 2022
New Therapeutic Targets Laboratory (TargetsLab)-Oncology Unit, Department of Medical Sciences, University of Girona, Girona, 17003, Spain.
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