We demonstrate the usefulness of "near real-time" neuro-navigation by open MRI systems for guidance of stereotactic evacuation of intracranial abscesses. A 70-year-old patient was referred to our institution with an intracranial left temporal abscess. He presented with headache, senso-motor aphasia and mild right hemiparesis. The abscess (35 x 25 mm) was stereotactically evacuated under MRI guidance, and a recurrence of a daughter abscess was again evacuated on the 9th postoperative day. "Near real-time" imaging showed an indentation of the abscess wall of 11 mm along the trajectory. A thermosensitive MRI protocol demonstrated a higher temperature around the abscess capsule than in the brain tissue more distant to the capsule, demonstrating the inflammatory process. The patient had 6 weeks of antibiotic therapy for gram-negative bacteria and was discharged with improved clinical symptoms 5 weeks after admission. Follow-up CT 2 months postoperatively showed a complete resolution of the abscess. Open MRI-guided interventions with "near real-time" imaging demonstrate the anatomical changes during an ongoing procedure and can be accommodated for enhancing the overall precision of stereotactic procedures. Thermosensitive MRI protocols are capable of revealing temperature gradients around inflammatory processes.
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http://dx.doi.org/10.1007/s00234-001-0758-7 | DOI Listing |
Prev Vet Med
January 2025
University of Lyon - French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Laboratory of Lyon, Epidemiology and support to Surveillance Unit, Lyon, France. Electronic address:
In response to the increasing emergence of zoonotic pathogens, flexible, multisectoral surveillance systems capable of generating alerts thanks to rapid, nonspecific detection, are crucial before pathogens reach human populations. Syndromic surveillance has proven to be a breakthrough for near real-time disease surveillance in the public health sector. It relies on existing nonspecific data, usually collected for other purposes.
View Article and Find Full Text PDFJ Mass Spectrom
February 2025
Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, USA.
The development of a real-time system for characterizing individual biomolecule-containing aerosol particles presents a transformative opportunity to monitor respiratory conditions, including infections and lung diseases. Existing molecular assay technologies, although effective, rely on costly reagents, are relatively slow, and face challenges in multiplexing, limiting their use for real-time applications. To overcome these challenges, we developed digitalMALDI, a laser-based mass spectrometry system designed for single-particle characterization.
View Article and Find Full Text PDFFront Med (Lausanne)
December 2024
Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
The number of clinical studies and associated research has increased significantly in the last few years. Particularly in rare diseases, an increased effort has been made to integrate, analyse, and develop new knowledge to improve patient stratification and wellbeing. Clinical databases, including digital medical records, hold significant amount of information that can help understand the impact and progression of diseases.
View Article and Find Full Text PDFAppl Spectrosc
January 2025
Jiangsu Engineering Research Center for Dust Control and Occupational Protection, China University of Mining and Technology, Xuzhou, Jiangsu, China.
We present a near real-time measurement method that combines Raman and spark emission spectroscopy to quantitatively analyze the molecular structure of airborne single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs), as well as detect toxic metals within CNTs. A corona-based aerosol microconcentrator was used for airborne CNTs sampling to enhance the measurement accuracy and sensitivity. The intensity of the characteristic Raman bands of CNTs and atomic emission lines of metals exhibited a linear relationship with the analyte mass, yielding high coefficient values.
View Article and Find Full Text PDFVaccines (Basel)
November 2024
Bill & Melinda Gates Foundation, Seattle, WA 98109, USA.
Although wild poliovirus type 2 has been eradicated, the prolonged transmission of the live- attenuated virus contained in the type-2 oral polio vaccine (OPV2) in under-immunized populations has led to the emergence of circulating vaccine-derived poliovirus type 2 (cVDPV2). The novel OPV2 (nOPV2) was designed to be more genetically stable and reduce the chance of cVDPV2 emergence while retaining comparable immunogenicity to the Sabin monovalent OPV2 (mOPV2). This study aimed to estimate the relative reduction in the emergence risk due to the use of nOPV2 instead of mOPV2.
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