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Bactericidal efficacy of low dose gaseous ozone against clinically relevant multidrug-resistant bacteria.
Front Microbiol
December 2024
Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA, United States.
Introduction: Healthcare-associated infections (HAIs) pose a significant challenge in acute care hospitals, particularly in intensive care units, due to persistent environmental contamination despite existing disinfection protocols and manual cleaning methods. Current disinfection methods are labor-intensive and often ineffective against multidrug-resistant (MDR) pathogens, highlighting the need for new, automated, hands-free approaches.
Methods: This study evaluates the bactericidal efficacy of low concentrations of gaseous ozone (5 ppm) against clinically relevant and often MDR bacteria under various concentrations, contact times, temperatures, and environmental conditions.
Can screening and decontamination procedures performed on an outpatient basis reduce the colonization with Staphylococcus aureus and mitigate associated complications in patients undergoing elective hospital procedures? A controlled intervention study (STAUfrei).
J Hosp Infect
December 2024
Kliniken Landkreis Heidenheim, Heidenheim, Germany.
Background: Staphylococcus aureus (SA) colonisation increases the risk of wound infections in surgical procedures. Prevention strategies to date have focused primarily on the hospital, although there are recommendations for pre-hospital decontamination at home, which can be performed by patients themselves. The current study aimed to shift the process of screening and decontamination of SA (methicillin-resistant S.
View Article and Find Full Text PDFIn-vitro and in-use efficacy of a rapid, targeted UVC decontamination system.
J Hosp Infect
January 2025
Environmental Research Laboratory, University College London Hospital, London, UK.
Background: Ultraviolet C (UVC) decontamination systems are used in healthcare to supplement manual cleaning. Systems typically target whole rooms with fixed, vertical bulbs.
Aim: To evaluate the in-vitro and in-use efficacy of the novel device with emitters on articulating arms designed for rapid, targeted decontamination in a hospital room.
Microorganisms isolated from thermoplastic masks and storage racks in head and neck cancer patients with radiation dermatitis.
Sci Rep
November 2024
Department of Radiation Oncology, Akdeniz University School of Medicine, Antalya, Turkey.
Healthcare-associated infections (HAIs) remain a critical public health issue, as they contribute to prolonged treatment duration, increased healthcare costs, and heightened risks of morbidity and mortality. In head and neck cancer patients undergoing radiotherapy, thermoplastic masks (TMs), which come into direct contact with the skin, represent a potential vector for infection. Additionally, the storage racks where these masks are kept may also facilitate microorganism transmission.
View Article and Find Full Text PDFEvaluation of an automated far ultraviolet-C light technology for decontamination of surfaces and aerosolized viruses in bathrooms.
Antimicrob Resist Infect Control
September 2024
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Background: Aerosols generated during toilet flushing are a potential source for transmission of viral and bacterial pathogens in bathrooms. However, manual decontamination of bathrooms after each use is not feasible.
Methods: We tested the efficacy of a wall-mounted far ultraviolet-C (UV-C) light technology that only delivers far UV-C when people are not present for decontamination of surfaces and aerosolized viral particles in an unoccupied hospital bathroom.
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