A differential pulse polarographic method is described for detection and trace determination of benzophenone (the main impurity) in phenytoin powder. The method depends upon the polarographic activity of benzophenone in Britton-Robinson buffer pH 5.6. The limit of detection was found to be 2.5 x 10(-6) microg ml(-1). Phenytoin has been analysed polarographically after oxidation with alkaline permanganate to give benzophenone; the limit of detection was found to be 6 x 10(-6) microg ml(-1).
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