Breast reconstruction after traditional radical mastectomy is particularly challenging for the plastic surgeon. Not only the breast, but subclavian and anterior axillary-fold deformities need to be corrected. An entire TRAM flap (including zone IV) is required, and bipedicled deep inferior epigastric vessels are needed to insure that the entire flap will survive completely. However, on the chest, it is difficult to locate the two suitable sets of recipient vessels for the two pedicles. The thoracodorsal vessels have usually been damaged during axillary dissection or radiation therapy. In the past, the proximal ends of the internal mammary artery and vein (IMA, IMV) have been used as recipient vessels with free flaps, with ligation of the distal ends. These authors have used both the proximal and distal ends of the IMA and IMV as recipient vessels for end-to-end anastomoses to the bipedicled deep inferior epigastric vessels (DIEA, DIEV) in seven clinical cases, with very satisfactory results obtained. Anatomic studies of the IMA and IMV were done in 10 dogs and two active patients, including studying hemodynamic changes at the proximal and distal ends of the IMA, and evaluation of perfusion units in the free bilateral TRAM flap. In the animal experiments, the mean pressure at the distal ends was 86/77 mmHg (left sides) and 87/78 mmHg (right sides); pressure was 63 to 71 percent of the proximal ends (p<0.05). There was no statistically significant difference between the pressures on the left and right sides. In the two patients, and in 5 others, the pressure at the distal ends was 66 and 58 mmHg, which was 75 to 77% of the pressure at the proximal ends. The blood flow at the two anastomotic stomas was similar in a 5-year follow-up. The clinical and experimental studies showed that the distal IMA has reduced perfusion pressure, but that it provides excellent flow and flap perfusion, allowing reliable use of two pedicles for survival of the entire flap.
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http://dx.doi.org/10.1055/s-2002-28498 | DOI Listing |
LINE-1 (L1) retrotransposition is widespread in many cancers, especially those with a high burden of chromosomal rearrangements. However, whether and to what degree L1 activity directly impacts genome integrity is unclear. Here, we apply whole-genome sequencing to experimental models of L1 expression to comprehensively define the spectrum of genomic changes caused by L1.
View Article and Find Full Text PDFJ Vet Med Sci
December 2024
The University Museum, The University of Tokyo.
The significance of forelimb morphology has been discussed with a focus on specific morphological aspects; nonetheless, the correlation of overall morphology, including various linear measurements, with respect to ecological preference and adaptation has not been extensively explored, particularly using multiple taxa. We investigated the morphological characteristics of the long bones in the forelimbs of mammalian species and their relationship with specific functional adaptations using 20 linear measurements and 22 terrestrial species from 7 orders. Principal component analysis and canonical discriminant analysis showed that the lengths of the humerus, radius, and ulna as well as the distance from the smallest width to the proximal and distal ends, and the deltoid tuberosity length distinguished four adaptations: arboreal, terrestrial, fossorial, and semi-aquatic.
View Article and Find Full Text PDFJ Cardiothorac Surg
December 2024
Department of Cardiology, Barzilai Medical Center, The Ben-Gurion University of the Negev, Hahistadrout 2, 7830604, Ashkelon, Israel.
Background: Giant coronary artery aneurysms are rare conditions with potentially devastating consequences. We report a case of the largest documented giant right coronary artery (RCA) aneurysm to date.
Case Presentation: A 57-year-old male patient visited our outpatient clinic for abdominal pain and exertional dyspnea.
J Biol Chem
December 2024
The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China; Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, Hunan, China; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, China. Electronic address:
Voltage-gated sodium (Nav) channels are transmembrane proteins that play crucial roles in the initiation and propagation of action potentials (APs) in excitable tissues such as the heart, muscles, and nerves. The distal ends of the four domain S6 segments of Nav channels contain hydrophobic residues, which form an intracellular gate. This gate allows Nav channels to control ion flux in excitable cells by opening and closing.
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