Unlabelled: The effects of insulin-like growth factor I (IGF-I) and insulin on free fatty acid (FFA) and glucose metabolism were compared in eight control and eight type 2 diabetic subjects, who received a two-step euglycemic hyperinsulinemic (0.25 and 0.5 mU x kg(-1) x min(-1)) clamp and a two-step euglycemic IGF-I (26 and 52 pmol x kg(-1) x min(-1)) clamp with [3-(3)H]glucose, [1-(14)C]palmitate, and indirect calorimetry. The insulin and IGF-I infusion rates were chosen to augment glucose disposal (R(d)) to a similar extent in control subjects. In type 2 diabetic subjects, stimulation of R(d) (second clamp step) in response to both insulin and IGF-I was reduced by approximately 40-50% compared with control subjects. In control subjects, insulin was more effective than IGF-I in suppressing endogenous glucose production (EGP) during both clamp steps. In type 2 diabetic subjects, insulin-mediated suppression of EGP was impaired, whereas EGP suppression by IGF-I was similar to that of controls. In both control and diabetic subjects, IGF-I-mediated suppression of plasma FFA concentration and inhibition of FFA turnover were markedly impaired compared with insulin (P < 0.01-0.001). During the second IGF-I clamp step, suppression of plasma FFA concentration and FFA turnover was impaired in diabetic vs. control subjects (P < 0.05-0.01).
Conclusions: 1) IGF-I is less effective than insulin in suppressing EGP and FFA turnover; 2) insulin-resistant type 2 diabetic subjects also exhibit IGF-I resistance in skeletal muscle. However, suppression of EGP by IGF-I is not impaired in diabetic individuals, indicating normal hepatic sensitivity to IGF-I.
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http://dx.doi.org/10.1152/ajpendo.00335.2001 | DOI Listing |
Int J Surg
January 2025
Department of General Surgery.
Objective: Gallstones have gradually become a highly prevalent digestive disease worldwide. This study aimed to investigate the association of nine different obesity-related indicators (BRI, RFM, BMI, WC, LAP, CMI, VAI, AIP, TyG) with gallstones and to compare their predictive properties for screening gallstones.
Methods: Data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) for the 2017-2020 cycle, and weighted logistic regression analyses with multi-model adjustment were conducted to explore the association of the nine indicators with gallstones.
Curr Diab Rep
January 2025
Department of Psychological Sciences, University of California, Merced, CA, USA.
Purpose Of Review: Insulin restriction is commonly studied as a form of disordered eating, but people may restrict insulin for many reasons. This systematic review examined how insulin restriction has been conceptualized and measured, and its associated predictors and outcomes.
Recent Findings: Forty-seven unique articles measured non-specified insulin restriction (IR), insulin restriction specifically for weight control (IRWC), or both.
Cureus
January 2025
Department of Preventive Dental Sciences, College of Dentistry, Najran University, Najran, SAU.
Aim And Background: The success of dental implants is contingent upon various biological conditions, and any lapse in meeting these criteria can lead to complications such as peri-implantitis or implant failure. The objective of this research is to evaluate the level of understanding regarding peri-implant among general dentists practicing in Saudi Arabia.
Materials And Methods: A quantitative approach was employed, utilizing an online questionnaire distributed to general dental practitioners (GDPs) in Saudi Arabia.
Cureus
December 2024
Department of Ophthalmology, College of Medicine, Qassim University, Kingdom of Saudi Arabia, Buraidah, SAU.
Background: Diabetic retinopathy (DR) is a significant microvascular complication of diabetes mellitus (DM), contributing to visual impairment and blindness worldwide. Understanding the factors associated with the severity of DR is crucial for effective prevention and management. This study aimed to explore the association between hemoglobin A1c (HbA1c) level and other parameters with different stages of DR.
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December 2024
Internal Medicine, Cooper University Hospital, Camden, USA.
This case report presents a complex and challenging scenario of recurrent () bacteremia and tricuspid valve endocarditis in a 77-year-old male patient with multiple comorbidities and indwelling medical devices. The patient's medical history was significant for T4 paraplegia, neurogenic bladder requiring a chronic indwelling suprapubic catheter, heart block status post-permanent pacemaker placement, type 2 diabetes mellitus, chronic kidney disease, and chronic sacral wounds. The case highlights the difficulties in managing antibiotic-resistant infections, particularly in patients with implantable devices and chronic wounds.
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