There is considerable interest in understanding the relation between random-matrix ensembles and quantum chaotic systems in the context of the universality of energy-level correlations. In this connection, while Gaussian ensembles of random matrices have been studied extensively, not much is known about ensembles with non-Gaussian weight functions. Dyson has shown that the n-level correlation functions can be expressed in terms of a kernel function involving orthogonal and skew-orthogonal polynomials--orthogonal for matrix ensembles with unitary invariance and skew orthogonal for ensembles with orthogonal and symplectic invariances. We have obtained the following results. (1) Skew-orthogonal polynomials of both types are derived for the Jacobi class of weight functions including the limiting cases of associated Laguerre and Hermite (or Gaussian). (2) Matrix-integral representations are given for the general weight functions. (3) Asymptotic forms of the polynomials are obtained rigorously for the Jacobi class and in the form of an ansatz for the general case. (4) For the three types of ensembles, the (asymptotic) n-level correlation functions with appropriate scaling are shown to be universal, being independent of the weight function and location in the spectrum, and identical with the well-known Gaussian results. This provides a rigorous justification for the universality of the Gaussian ensemble results observed in quantum chaotic systems. As expected, the level density is not universal.
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http://dx.doi.org/10.1103/PhysRevE.65.046221 | DOI Listing |
JAMA Pediatr
January 2025
Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Importance: Cyclophosphamide and calcineurin inhibitors are the most used nonsteroid immunosuppressive medications globally for children with various chronic inflammatory conditions. Their comparative effectiveness remains uncertain, leading to worldwide practice variation. Nephrotic syndrome is the most common kidney disease managed by pediatricians globally and suboptimal treatment is associated with high morbidity.
View Article and Find Full Text PDFNeurochem Res
January 2025
Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Our aim was to evaluate the regulation of messenger RNAs (mRNAs) and biological pathways by long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in ischemic stroke. We employed weighted gene co-expression network analysis (WGCNA) to construct two co-expression networks for mRNAs with circRNAs and lncRNAs, respectively, to investigate their association with ischemic stroke. We compared the overlap of mRNAs and biological pathways in the stroke-associated modules of the two networks.
View Article and Find Full Text PDFHistochem Cell Biol
January 2025
Medical Histology and Cell Biology Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
Gestational diabetes mellitus (GDM) significantly disrupts placental structure and function, leading to complications such as intrauterine growth restriction (IUGR) and preeclampsia. This study aimed to investigate the effects of GDM on placental histology, angiogenesis, and oxidative stress, as well as evaluate metformin's protective role in mitigating these changes. A total of 60 pregnant Sprague-Dawley rats were divided into four groups: control, metformin-treated, GDM, and GDM with metformin.
View Article and Find Full Text PDFCurr Diab Rep
January 2025
Department of Psychological Sciences, University of California, Merced, CA, USA.
Purpose Of Review: Insulin restriction is commonly studied as a form of disordered eating, but people may restrict insulin for many reasons. This systematic review examined how insulin restriction has been conceptualized and measured, and its associated predictors and outcomes.
Recent Findings: Forty-seven unique articles measured non-specified insulin restriction (IR), insulin restriction specifically for weight control (IRWC), or both.
Eur J Phys Rehabil Med
January 2025
Preventive Medicine, Epidemiology and Public Health Area, Department of Biomedical and Diagnostic Sciences, University of Salamanca, Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain -
Background: Neck and back pain pathologies are currently the main cause of absenteeism from work in Spain and in the European Union, and represent a high socio-labor, economic and health cost for the Health Systems.
Aim: To assess the effectiveness of a Back School Program of a Spanish mutual insurance company (risk factors, pain and disability scales) in women workers with low back or neck pain.
Design: We combined a descriptive study of first-session data collected in the total sample and a prospective multicenter intervention study in those participants who completed the second and third check-up at 6 and 9 months.
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