High energy heavy-ion collisions are proposed as a novel means to constrain stringently the high density (HD) behavior of nuclear symmetry energy. Within an isospin-dependent hadronic transport model, it is shown for the first time that the isospin asymmetry of the HD nuclear matter formed in high energy heavy-ion collisions is uniquely determined by the HD behavior of the nuclear symmetry energy. Experimental signatures in two sensitive probes, i.e., pi(-) to pi(+) ratio and neutron-proton differential collective flow, are also investigated.
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