Escherichia coli cells expressing the tpm gene encoding the bacterial thiopurine methyltransferase (bTPMT) are shown to methylate selenite and (methyl)selenocysteine into dimethylselenide (DMSe) and dimethyldiselenide (DMDSe). E. coli cells expressing tpm from a gene library cosmid clone (harboring a Pseudomonas syringae insert of about 20 kb) also methylated selenate into DMSe and DMDSe. bTPMT is the first methyltransferase shown to be involved in the methylation of these selenium derivatives.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135077 | PMC |
| http://dx.doi.org/10.1128/JB.184.11.3146-3149.2002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Key Focus Areas in Pouchitis Therapeutic Status: A Narrative Review.
Iran J Med Sci
August 2024
Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, Iran.
Article Synopsis
- Pouchitis is a common complication after ileal pouch-anal anastomosis (IPAA), affecting 7% to 46% of patients, and its treatment remains poorly understood.
- Effective diagnosis involves assessing symptoms, endoscopic findings, and specific tests, while treatment options range from antibiotics and probiotics to more advanced therapies like anti-tumor necrosis factor medications and fecal microbiota transplantation.
- Improving pouchitis management is crucial due to its impact on quality of life, necessitating more focused research to determine optimal treatment strategies.
Factors contributing to flares of ulcerative colitis in North India- a case-control study.
BMC Gastroenterol
September 2023
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- Ulcerative colitis is a relapsing disease with unpredictable flare-ups, and the study aimed to identify potential causes of these flares in patients from North India.* -
- The study involved 84 participants, comparing those experiencing flares with those in remission, examining factors like recent infections, stress, and medication adherence.* -
- Results showed that higher rates of non-adherence to treatment and a reliance on complementary therapies were observed in patients with flares, with reasons for non-adherence including therapy costs and misconceptions about their condition.*
Thiopurines Analogues with Additional Ring: Synthesis, Spectroscopic Properties, and Anticancer Potency.
Int J Mol Sci
May 2023
Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, 61-614 Poznan, Poland.
Purine scaffolds constitute a starting point for the synthesis of numerous chemotherapeutics used in treating cancer, viruses, parasites, as well as bacterial and fungal infections. In this work, we synthesized a group of guanosine analogues containing an additional five-membered ring and a sulfur atom at the C-9 position. The spectral, photophysical, and biological properties of the synthesized compounds were investigated.
View Article and Find Full Text PDFManagement of patients with Intestinal Bowel Disease and COVID-19: A review of current evidence and future perspectives.
Gastroenterol Hepatol
May 2022
Digestive Disease Department, University of Valencia, Clinic University Hospital of Valencia, Valencia 46010, Spain.
The COVID-19 pandemic has been a challenge for countries and health professionals worldwide. Viral entry by ACE-2 receptor and an excessive activation of the immune system are key to understand both incidence and severity of disease. Inflammatory Bowel Disease (IBD) represents a special condition associated with an inordinate response of the immune system to external agents.
View Article and Find Full Text PDFManagement of cutaneous side effects of inflammatory bowel disease therapy: A dermatologic viewpoint.
J Gastroenterol Hepatol
December 2021
Section of Gastroenterology and Hepatology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Medications used in the treatment of inflammatory bowel disease cause a wide range of dermatologic side effects, and minimal guidance exists on how to manage them. The intention of this review article is to summarize common dermatologic adverse reactions related to inflammatory bowel disease therapy and to provide evidence-based guidance on management. We conducted a scoping review using PubMed and Google Scholar to identify studies reporting clinical information on dermatologic side effects of medications used in the treatment of inflammatory bowel disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!