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Native mercury, hydrargyrism and the birth of occupational toxicology in Colombia.
Environ Geochem Health
January 2025
Public Health Department, School of Medicine, Universidad Industrial de Santander, Bucaramanga, Colombia.
The "La Esperanza" native mercury mine in Aranzazu, (Caldas, Colombia) was active from 1948 until 1975. Before the final closure of the mine, the company began using dimercaprol (BAL, British Anti-Lewisite) and penicillamine for the treatment of hydrargyrism among workers. Mercury poisoning among miners was frequent due to precarious working conditions, inadequate technology, difficult terrain, and the high toxicity of native mercury within the mine.
View Article and Find Full Text PDFClinical Efficacy of Intravenous Papaverine plus Ketorolac in the Emergency Treatment of Renal Colic: A Randomized, Double-blind Clinical Trial.
Iran J Med Sci
November 2024
Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Acute renal colic has been challenging and has brought many concerns for physicians and patients for centuries. This study aimed to evaluate the analgesic effect and safety of a combination of papaverine and ketorolac against ketorolac and placebo in treating acute renal colic.
Methods: This randomized clinical trial was performed in patients with renal colic from May 2018 to May 2020 in Ahvaz, Iran.
In pursuit of a functional cure for follicular lymphoma.
Hematology Am Soc Hematol Educ Program
December 2024
Concord Repatriation General Hospital, University of Sydney, Concord, NSW, Australia.
We are now a quarter of a century after the transformative impact of rituximab in improving overall survival for patients with follicular lymphoma. With a burgeoning array of effective immunochemotherapy approaches, we can now frame many patients' expectations of longevity and a "functional cure," with survival estimates for many newly diagnosed patients comparable to age- and gender-matched populations. We highlight not just heterogeneity in disease but also in patients, which influences therapeutic decision-making in an immunochemotherapy era where progression-free survival advances are associated with efficacy-toxicity trade-offs, and no clear overall survival advantage is associated with any specific regimen.
View Article and Find Full Text PDFBioavailability of ursolic/oleanolic acid, with therapeutic potential in chronic diseases and cancer.
Adv Clin Exp Med
November 2024
Department of Bioresources and Polymer Sciences, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology, Bucharest, Romania.
This study focused on describing the bioavailability of ursolic/oleanolic acids (UA/OA) and the methods to increase it, so that these 2 bioactive compounds can have therapeutic and preventive effects in chronic diseases and cancer. Ursolic/oleanolic acids are natural compounds that have been known since the 19th century. They are very widespread and offer special benefits for human health - especially that their high absorbability makes them suitable for use in therapeutic and preventive treatment.
View Article and Find Full Text PDFA simplified geriatric prognostic index to survival in older Asian patients with diffuse large B-Cell lymphoma treated with standard chemo-immunotherapy.
Ann Hematol
December 2024
Division of Medical Oncology, National Cancer Centre Singapore, 30 Hospital Blvd, Singapore, 168583, Singapore.
While there are many proposed clinical prediction models for diffuse large B-cell lymphoma, like the International Prognostic Index (IPI), revised IPI and the National Comprehensive Cancer Network IPI, there is no widely used model for older patients. A recent study proposed a Geriatric Prognostic Index (GPI) validated in a Norwegian cohort, using independent predictors involving demographic, biochemical and functional parameters. This study aims to validate the GPI in an Asian cohort and simplify the GPI for ease of clinical application.
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