Self-assembly of molecular capsules in polar solvents.

Org Lett

Fachbereich Chemie, Universität Marburg, Hans-Meerwein-Strasse 35032, Germany.

Published: May 2002

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Article Abstract

[structure: see text] We present a novel type of molecular capsule formed by self-organization of calix[4]arenes with several oppositely charged functional groups located at their upper rims. In highly polar solvents, the complementary half-spheres form stable 1:1 complexes with association constants of up to 7 x 10(5) M(-)(1) in methanol. The cavity inside the capsules is large enough for the inclusion of small aliphatic or (hetero)aromatic guest molecules.

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http://dx.doi.org/10.1021/ol0257631DOI Listing

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