To study ileal motility, 14 young turkeys were surgically prepared with a fistula and 3 bipolar Ag/AgCl electrodes in the ileum. Electric slow waves were recorded which averaged 0.45 mV in amplitude and 6.1 waves/min in frequency. They seldom waned, had no wave-form characteristic of a particular region of the ileum, and action-potential bursts did not occur at a particular phase of the slow wave. Action potentials, associated with contractions, averaged 0.21 mV in amplitude. An average of 4.0 pressure changes occurrd per minute and their amplitude averaged 16.2 mm Hg. Slow waves apparently were the primary regulators of ileal motility, although another type of activity may also have been involved. The latter activity consisted of intensive action-potential activity associated with high-frequency, high-amplitude contractile activity which appeared to move periodically aborally down the ileum.
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Br J Pharmacol
January 2025
Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
Background And Purpose: Inflammatory bowel disease (IBD) patients display genetic polymorphisms in toll-like receptor 4 (TLR4) genes, contributing to dysregulate enteric nervous system (ENS) circuits with increased levels of 5-HT and alteration of the neuroimmune crosstalk. In this study, we investigated the impact of TLR4 signalling on mouse ENS dysfunction caused by dextran sulphate sodium (DSS)-induced ileitis.
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Vet Med Sci
January 2025
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Türkiye.
This study aimed to compare the inhibitory effect of flunixin meglumine and meloxicam on the smooth muscles of the gastrointestinal tract in male cattle. Tissue samples, including the abomasum, ileum, proximal loop and centripetal gyri of the ascending colon, were collected from routinely slaughtered male cattle. These samples were sectioned into strips and mounted in an isolated tissue bath system.
View Article and Find Full Text PDFWorld J Gastroenterol
January 2025
Department of Gastroenterology, The Air Force Medical Center, Beijing 100142, China.
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View Article and Find Full Text PDFPediatr Radiol
January 2025
Pediatric Gastroenterology, Medical College of Wisconsin, B610 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
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Objective: Our aim was to show that quantitative MRI correlates with magnetic resonance enterography (MRE).
Nutrients
December 2024
Food Chemistry and Nutraceutical Laboratory, Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Background: Three herbal extracts ( Willd., Lorentz, and L.) were mixed with three essential oils ( Mill.
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