Radioimmunotherapy for non-Hodgkin's lymphoma with yttrium 90 ibritumomab tiuxetan.
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Recent preclinical and clinical advances in radioimmunotherapy for non-Hodgkin's lymphoma.
Explor Target Antitumor Ther
February 2024
Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto 860-0811, Japan.
Article Synopsis
- * Two RIT agents, Zevalin and Bexxar, have been approved by the FDA for treating specific types of NHL, but their use has declined due to the rise of new therapies and complexities in administering them.
- * New advancements in RIT include novel targets, therapeutic strategies using alpha-particle isotopes for better tumor targeting, and the development of immuno-PET imaging for personalized treatment monitoring.
A Systematic Review of Clinical Applications of Anti-CD20 Radioimmunotherapy for Lymphoma.
Oncologist
April 2024
Division of Hematology and Oncology, University of Arizona School of Medicine, Tucson, AZ, USA.
Article Synopsis
- The study reviews the clinical efficacy and safety of anti-CD20 radioimmunotherapy (RIT) for treating indolent B-cell lymphomas, highlighting two approved agents: 90Y-ibritumomab tiuxetan and 131I-tositumomab.
- Numerous clinical trials support RIT's effectiveness, especially in high-risk and heavily pretreated patient populations, with manageable toxicity profiles.
- Continued research is needed to explore long-term response biomarkers and optimize RIT within treatment strategies, as it shows promise for sustained remission and serves as a viable alternative to other therapies.
The asymptomatic follicular lymphoma (AFL) trial: single-agent rituximab immunotherapy versus 90Y-ibritumomab tiuxetan radioimmunotherapy (RIT) for patients with new, untreated follicular lymphoma.
Leuk Lymphoma
March 2024
Division of Hematology, Department of Medicine, Mayo Clinic Rochester, MN, USA.
Patients with asymptomatic follicular lymphoma (AFL) are candidates for observation or immunotherapy. Given the effectiveness of radiation therapy in FL, another option is 90Yttrium-ibritumomab tiuxetan radioimmunotherapy (RIT). We conducted a trial where untreated AFL patients were randomized to rituximab 375 mg/m2 weekly × 4 or rituximab 250 mg/m days 1, 8, and 0.
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