AI Article Synopsis
- The study explored how the thyroid hormone thyroxine affects energy production in rat thymus lymphocytes and their isolated mitochondria.
- It was found that while thyroxine decreased the respiration rate stimulated by protonophoric uncouplers in intact lymphocytes, it did not exert the same effect in isolated mitochondria.
- The researchers suggest that aromatic uncouplers may enter the cell via the same carrier as thyroxine, leading to varying effects on cellular respiration.
Article Abstract
Earlier we reported that some thyroid and steroid hormones and also 6-ketocholestanol used in micromolar concentrations modulated the effects of protonophoric uncouplers on isolated mitochondria (Starkov et al. (1997) Biochim. Biophys. Acta, 1318, 173-183). In the present study we investigated the effects of a thyroid hormone, thyroxine, on energy coupling of intact rat thymus lymphocytes and mitochondria isolated from these cells. The resting (oligomycin-inhibited) respiration of the isolated intact lymphocytes was stimulated by the addition of protonophoric uncouplers 2,4-DNP, FCCP, or SF6847. Subsequent addition of micromolar concentrations of thyroxin decreased the rate of uncoupler-stimulated respiration and partially reversed uncoupler-induced decrease of membrane potential (DeltaPsi). In experiments with mitochondria isolated from thymus lymphocytes the re-coupling effect of thyroxine was not observed. In this case thyroxine did not influence mitochondrial respiration stimulated with 2,4-DNP, but did potentiate the stimulation of respiration and DeltaPsi decrease induced with another uncoupler, SF6847. The data are discussed in terms of a hypothesis that aromatic uncouplers are transported into the cell by the thyroxine carrier of the plasma membrane.
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| http://dx.doi.org/10.1023/a:1015242224909 | DOI Listing |
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