Furosemide and spironolactone reduce transmigration of leukocytes through endothelial cell monolayers. Leukocytes play a tremendous role during inflammation. Leukocytes migrate from intravascular space into the tissue to attack microorganisms. Various agents are able to influence leukocyte recruitment. The influence of diuretics, such as furosemide and spironolactone, on inflammatory processes is not well known. The aim of our study was to examine the influence of furosemide and spironolactone on leukocyte migration through endothelial cell monolayers (ECM). Human umbilical vein endothelial cells were cultured on microporous membranes achieving a monolayer. Polymorphonuclear leukocytes (PMNL) were used in a currently described migration assay. PMNL and/or ECM were pretreated with furosemide and spironolactone using therapeutic, as well as higher and lower, concentrations. Furosemide (76 +/- 7.2%) and spironolactone (70 +/- 7.7%) were able to inhibit PMNL migration through ECM significantly, when both cell types were treated simulating the situation after an iv injection. Furosemide and spironolactone were identified as potent inhibitors of leukocyte migration through ECM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/15287390252900386 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Congenital anomalies associated with the use of cardiovascular drugs during pregnancy: a large-scale data analysis from the FAERS database.
Expert Opin Drug Saf
December 2024
School of Pharmaceutical Sciences, Jinan University, Guangzhou, Guangdong Province, China.
Background: Cardiovascular drugs can cross the placenta during pregnancy, potentially exposing the fetus to teratogenic effects. However, ethical constraints on clinical trials with pregnant women limit safety data and result in inadequate drug labeling.
Research Design And Methods: Using the FAERS database (2004-2023), we conducted a retrospective pharmacovigilance study analyzing adverse event reports involving congenital anomalies in newborns (<28 days).
Angiotensin-Converting Enzyme Inhibitor (ACEI) and Angiotensin Receptor Blocker (ARB) Use are Associated With Increased Readmission After Ileostomy Creation.
Am Surg
December 2024
Kaiser Permanente Northwest, Portland, OR, USA.
Background: High output is a common cause for readmission after new ileostomy creation. The loss of sodium leads to compensatory activation of the renin-angiotensin-aldosterone system (RAAS). Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) are first-line therapy for hypertension in the United States.
View Article and Find Full Text PDFManagement of Cardiac Involvement in Becker Muscular Dystrophy: A Case Report.
Cureus
November 2024
Cardiovascular Disease, University Hospital Center "Mother Teresa", Tirana, ALB.
Becker muscular dystrophy (BMD) is an X-linked recessive neuromuscular disorder caused by a mutation in the dystrophin gene. Cardiac involvement is a frequent finding in BMD, and manifestations may vary from asymptomatic cardiac involvement to developing symptoms of heart failure and severe cardiomyopathy. We presented the case of a 32-year-old wheelchair-dependent BMD patient who came to our cardiology clinic with a two-month history of heart palpitations, rest and nocturnal dyspnea, fatigue, and generalized muscular weakness.
View Article and Find Full Text PDFAmphetamine-Dextroamphetamine-Induced Cardiomyopathy: A Case Report on Heart Failure in a Young Addict.
Cureus
October 2024
Cardiology, Althager General Hospital, Jeddah, SAU.
Article Synopsis
- * A case study of a 32-year-old man revealed his heart failure with reduced ejection fraction was associated with amphetamine use, raising concerns about drug-induced deterioration of existing heart conditions.
- * Effective management of patients with ADHD and heart issues requires careful monitoring by a multidisciplinary team and a complete pharmaceutical regimen to prevent further cardiac problems.
The Hidden Culprit: A Computed Tomography Diagnosis of H-Type Tracheoesophageal Fistula in an Adult Revealed After Two Decades of Pulmonary Infections.
Cureus
October 2024
Radiology, Souss Massa University Hospital, Agadir, MAR.
Article Synopsis
- A 41-year-old male with a history of cardiopathy and respiratory issues presented with severe symptoms related to heart failure, including significant dyspnea and edema after years of recurrent infections.
- Diagnostic tests revealed multiple complications including dilation of cardiac chambers and a rare congenital condition known as H-type tracheoesophageal fistula (TEF), which contributed to his respiratory problems.
- The patient was admitted to the ICU for intensive management, including treatment for pulmonary artery hypertension and preparation for surgical intervention to repair the fistula.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!