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Association of SSRI and SNRI use with incident hyponatremia after subarachnoid hemorrhage.
Clin Neurol Neurosurg
December 2024
Department of Pharmacy, Massachusetts General Hospital, Boston, MA, United States.
Background: Hyponatremia is common following subarachnoid hemorrhage (SAH) and is associated with vasospasm and delayed cerebral ischemia (DCI). Risk factors for post-SAH hyponatremia are poorly defined; however, selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs) are associated with hyponatremia in non-SAH populations. This study assessed whether pre-admission SSRIs/SNRIs were associated with hyponatremia after SAH.
View Article and Find Full Text PDFHyponatremia Associated with the Use of Common Antidepressants in the All of Us Research Program.
Clin Pharmacol Ther
February 2025
Precision Health Informatics Section, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Article Synopsis
- This study investigates the risk of hyponatremia (low sodium levels) associated with various antidepressants, including SSRIs, SNRIs, and NRIs, through examination of health records in the All of Us Research Program.
- The overall incidence of hyponatremia was found to be 0.87% within the first 30 days and 10.5% over three years among participants taking these medications.
- Among the antidepressants studied, duloxetine and escitalopram had the highest risk for hyponatremia, while bupropion and paroxetine were linked to the lowest risk, helping providers make informed treatment decisions.
Hyponatremia-associated hospital visits are not reduced by early electrolyte testing in older adults starting antidepressants.
J Am Geriatr Soc
June 2024
ICES, Toronto, Ontario, Canada.
Background: Clinical practice guidelines recommend early serum electrolyte monitoring when starting antidepressants in older adults due to the increased risk of hyponatremia. It is unclear whether this monitoring improves outcomes.
Methods: Population-based, retrospective cohort study of Ontario adults aged ≥66 years who initiated therapy with a selective serotonin reuptake inhibitor (SSRI) or selective norepinephrine reuptake inhibitor (SNRI) between April 1, 2013, and January 31, 2020.
SSRI/SNRI -induced Hyponatremia: A Case Series of 26 Patients in a Single Institution from 2018 to 2020.
Psychiatr Q
June 2023
Department of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application (Beijing Hospital), Beijing, 100730, People's Republic of China.
Antidepressant medications are widely used by patients with depression or a depressive disorder. In spite of a generally favorable safety profile of selective serotonin reuptake inhibitors or serotonin - norepinephrine reuptake inhibitors (SSRI/SNRI), several cases of a possible connection between SSRI/SNRI and hyponatremia have been reported. To describe the clinical characteristics of patients with hyponatremia after SSRI/SNRI exposure, and to examine the association between SSRI/SNRI exposure and the presence of hyponatremia in a Chinese population.
View Article and Find Full Text PDFFluoxetine or Venlafaxine for Early Post Stroke Depression.
Neurol India
December 2022
Assistant Professor, Division of Stroke Medicine, Centre for Neurosciences, Amrita Institute of Medical Sciences, Ponekkara, Kochi, Kerala, India.
Context: Post stroke depression (PSD) is an under diagnosed morbidity of stroke and can negatively affect the prognosis of the patient.
Aims: We intended to study the prevalence of PSD and the commonly used anti-depressants and their outcome in patients with PSD.
Settings And Design: A prospective observational study was conducted in the patients admitted to the stroke unit of a tertiary care centre.
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