AI Article Synopsis
- The study involved administering 2 gm/kg of intravenous gamma globulin (IVIG) to five patients with Landau-Kleffner syndrome over four days.
- A comparison of a severity score assessing various aspects like speech and seizures before and after treatment showed a significant improvement (P = 0.025).
- Two patients experienced a complete resolution of symptoms, indicating that IVIG may be an effective treatment option for this syndrome.
Article Abstract
We administered 2 gm/kg of intravenous gamma globulin (IVIG) to each of five consecutive patients with Landau-Kleffner syndrome, over 4 days. We compared the 1-month baseline to that following IVIG using a severity score assessing speech, comprehension, behavior, seizures, and electroencephalography. There was a significant drop in this score after IVIG (P = 0.025). Two patients had a dramatic response to IVIG, with complete resolution of symptoms. This finding suggests that IVIG has at least some efficacy for the therapy of Landau-Kleffner syndrome.
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| http://dx.doi.org/10.1016/s0887-8994(01)00402-7 | DOI Listing |
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