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Bioreactor developments for tissue engineering applications by the example of the bioartificial liver. | LitMetric

Bioreactor developments for tissue engineering applications by the example of the bioartificial liver.

Adv Biochem Eng Biotechnol

Experimental Radiology, Hepatic Tissue Engineering, Medical School Hannover, Germany.

Published: June 2002

AI Article Synopsis

  • Tissue engineering combines engineering methods and life sciences to create biological substitutes for restoring or improving bodily functions, gaining global significance.
  • The article discusses advancements in tissue engineering, specifically focusing on the bioartificial liver as a potential alternative to liver transplantation.
  • Effective artificial liver support systems must perform key liver functions like detoxification and metabolism, but there is no agreed-upon design for these systems as various approaches have been proposed.

Article Abstract

Tissue engineering is the application of the principles and methods of engineering and the life sciences towards the development of biological substitutes to restore, maintain or improve functions. It is an area which is emerging in importance worldwide. This article is to show the developments in tissue engineering research by the example of the bioartificial liver. As an alternative to liver transplantation, numerous researchers have been working towards the goal of development of a fully functional artificial liver. Liver support systems based on detoxification alone have proven ineffective because they cannot correct biochemical disorders. An effective artificial liver support system should be capable of carrying out the liver's essential processes, such as synthetic and metabolic functions, detoxification, and excretion. It should be capable of sustaining patients with fulminant hepatic failure and preparing patients for liver transplantation when a donor liver is not readily available. Although several hepatocyte-based liver support systems have been proposed, there is no current consensus on its eventual design configuration.

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Source
http://dx.doi.org/10.1007/3-540-45736-4_5DOI Listing

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