The reaction of 2,3.4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide with a 6-aryl-5-cyano-2-(methylthio)pyrimidin-4(3H)one in aqueous acetone in the presence of KOH furnishes a 4-(beta-D-glucopyranosyloxy)pyrimidine and a 3-(beta-D-glucopyranosyl)pyrimidine as the major and minor product. respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1081/NCN-120006527 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enzymatic modification of dihydromyricetin by glucosylation and acylation, and its effect on the solubility and antioxidant activity.
Org Biomol Chem
December 2024
Instituto de Catálisis y Petroleoquímica, CSIC, 28049 Madrid, Spain.
Although dihydromyricetin exhibits strong potential for pharmaceutical applications, its limited aqueous solubility, permeability and stability restrict its use. In this work, we have synthesized a series of glucosides and acyl-glucosides of dihydromyricetin that could increase the bioavailability of this molecule. First, the R134A variant of sucrose phosphorylase from catalyzed the formation of three monoglucosides, and the major one was identified as dihydromyricetin 4'--α-D-glucopyranoside (>75% conversion yield).
View Article and Find Full Text PDFNew Insights into pH-dependent Complex Formation between Lignosulfonates and Anthocyanins: Impact on Color and Oxidative Stability.
J Agric Food Chem
December 2024
LAQV - REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 687, Porto 4169-007, Portugal.
Anthocyanins have limited application as natural colorants and antioxidants due to their color loss and instability under certain conditions. This research explores the formation of a complex between lignosulfonates (LS) and cyanidin-3--glucoside (C3G) using a multitechnique approach as well as the effect on C3's red color, oxidative stability, and antioxidant activity in acidic mediums. All data revealed pH-dependent LS-C3G interactions.
View Article and Find Full Text PDFChemical Synthesis of 6-Azido-6-Deoxy Derivatives of Phosphatidylinositol Containing Different Fatty Acid Chains.
Molecules
October 2024
Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
This paper describes the synthesis of two 6-azido-6-deoxy derivatives of phosphatidylinositol (PI), which contained different fatty acid chains. These syntheses, starting from methyl α-d-glucopyranoside, employed multiple regioselective transformations with Ferrier rearrangement as one of the key steps. The PI derivatives contained different fatty acid chains in the lipids and an azido group in the inositol residue to facilitate their further functionalization under bioorthogonal conditions.
View Article and Find Full Text PDFPhytochemical analysis and evaluation of the inhibitory effect of the Cunila lythrifolia Benth aerial parts on abdominal pain and some digestive enzymes.
J Ethnopharmacol
January 2025
Jardín Botánico, Instituto de Biología, Universidad Nacional Autónoma de México. Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
Ethnopharmacology Relevance: Cunila lythrifolia Benth. (Lamiaceae) commonly named "poleo de monte" is a Mexican plant known since pre-Hispanic times because of the properties of its aerial parts to treat respiratory and gastrointestinal conditions, for postpartum care, and as an aphrodisiac.
Aim Of The Study: To obtain preclinical evidence of the pharmacological properties of C.
Progress in the study of anti-tumor effects and mechanisms of vitexin.
Pharmacol Rep
October 2024
School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Vitexin (apigenin-8-C-beta-D-glucopyranoside) is a natural flavonoid derivative with anti-cancer, antioxidant, anti-inflammatory, antihypertensive, anti-asthma, anti-epilepsy, and other therapeutic effects. It is extracted from pearl millet, hawthorn, pigeon bean, mung bean, and other medicinal plants. Vitexin has received widespread attention because of its significant anti-tumor effect.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!