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Cigarette smoke-induced epithelial cell ferroptosis promotes neutrophilic inflammation in patients with nasal polyps.
J Allergy Clin Immunol
March 2025
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, China; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Background: Regulation of epithelial cell death has emerged as a key mechanism maintaining immune homeostasis in the airway. However, the mechanisms governing epithelial cell survival in nasal polyps (NPs) remains poorly understood.
Objective: To investigate the ferroptosis of nasal epithelial cell and its implications in the pathogenesis of NPs.
Determinants of treatment response to cognitive behavioral therapy in veterans presenting with comorbid insomnia and sleep apnea.
Sleep Breath
March 2025
Sleep Disorders Research Center, VA Western New York Healthcare System, Buffalo, NY, USA.
Purpose: Although cognitive behavioral therapy for insomnia (CBT-I) is considered the preferred treatment for insomnia in patients with comorbid insomnia and obstructive sleep apnea (COMISA), the remission rate with CBT-I is generally considered lower than in insomnia-only populations. There is also a sizable variability in individual treatment responses. Due to the limited availability of CBT-I, we sought to identify specific clinical attributes that predict benefit from Brief Behavioral Therapy for Insomnia (BBTI)-an adaptation of CBT-I-in patients with COMISA.
View Article and Find Full Text PDFSoluble Factors and Mechanisms Regulated by Sialylated IgG Signaling.
Immunol Rev
March 2025
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Inflammation is a complex biological response that can be both induced and actively suppressed by IgG-Fc gamma receptor (FcγR) interactions. This review explores the role of IgG sialylation in reducing or blocking inflammatory responses. We first revisit foundational studies that established the anti-inflammatory properties of sialylated IgG1 Fc.
View Article and Find Full Text PDFThree locally invasive infantile fibrosarcoma cases treated with larotrectinib.
Turk J Pediatr
February 2025
Department of Pediatric Hematology and Oncology, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Türkiye.
Background: Infantile fibrosarcoma is a rapidly growing soft tissue tumor, often managed by surgical resection, with chemotherapy and radiotherapy as additional options. Due to the high local aggressiveness and surgical morbidity, targeted therapies like larotrectinib can enhance quality of life and preserve organs, particularly in limb-threatening cases. Here, we present three cases where larotrectinib prevented mutilating surgeries.
View Article and Find Full Text PDFMatrix metalloproteinase-7 and matrix metalloproteinase-9 expression is upregulated in congenital lung malformations.
Turk J Pediatr
February 2025
Department of Pediatric Surgery, Faculty of Medicine, Bursa Uludağ University, Bursa, Türkiye.
Background: Congenital lung malformations (CLMs) refer to structural abnormalities of the lungs that occur during fetal development. Matrix metalloproteinases (MMPs) constitute a group of zinc-dependent enzymes, with certain members of this family playing pivotal roles in the remodeling of the lungs both prenatally and postnatally. This study aimed to explore expression levels of MMP-2, MMP-7, and MMP-9 in CLMs which are recognized as pivotal contributors to their clinical pathology.
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