By measuring the residence time distribution (RTD) curve of shell side and tube side of hollow fiber modules, it was found that the flow status in hollow fiber module with moderate or low packing density was complicated. For tube side, there were deviation between the experimental RTD curves and the theoretical laminar flow ones, which indicated that the flow status in tube side was between laminar flow and turbulent flow. For shell side, the experimental RTD curves agreed well with the laminar flow ones. The deviations as low as +/- 5% between the experimental average residence times and the theoretical ones suggested that there was no apparent non-ideal flow in the hollow fiber module with medium packing density. Based on the comparison between the experimental results and some typical correlations, a new velocity profile was purposed to describe the flow status in hollow fiber modules. According to the results of cadmium transport, the individual mass transfer coefficient correlations were developed. The zinc outlet concentrations predicted by the new correlations agreed relatively well with the experimental results, the relative deviation was among +/- 25%.
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Bioprocess Biosyst Eng
January 2025
Cell Culture Development, Biogen, 5000 Davis Drive, Research Triangle Park, NC, 27709, USA.
Membrane fouling is a common and complex challenge with cell culture perfusion process in biopharmaceutical manufacturing that can have detrimental effects on the process performance. In this study, we evaluated a method to calculate the hollow fiber membrane resistance at different time points for water and supernatant. In addition, the number of subvisible particles of < 200 nm.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Nanjing Forestry University, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, CHINA.
Suboptimal spatial utilization and inefficient access to internal porosity preclude porous carbon cathodes from delivering high energy density in zinc-ion hybrid capacitors (ZIHCs). Inspired by the function of capillaries in biological systems, this study proposes a facile coordination-pyrolysis method to fabricate thin-walled hollow carbon nanofibers (CNFs) with optimized pore structure and surface functional groups for ZHICs. The capillary-like CNFs maximize the electrode/electrolyte interface area, facilitating the optimal utilization of energy storage sites.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Health Science and Technology, Aalborg University, Gistrup, 9260, Denmark.
Cryopreservation enhances the availability of "off-the-shelf" cell therapies. However, the choice between tissue culture polystyrene (TCP) and hollow fiber system (HFB) system for adipose-derived stem cell (ASC) production remains a critical decision, with implications for scalability, reproducibility, and the clinical efficacy. Therefore, the characteristics of ASCs expanded in TCP and HFB and cryopreserved were compared.
View Article and Find Full Text PDFChemosphere
December 2024
Zhejiang Provincial Key Laboratory for Subtropical Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou, China; Department of Chemical and Environmental Engineering, University of Nottingham Malaysia, B34, Semenyih, 43500, Selangor, Malaysia.
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).
View Article and Find Full Text PDFInt J Antimicrob Agents
December 2024
Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:
Mycobacterium avium complex bacteria cause chronic pulmonary disease (MAC-PD) in susceptible patients [1]. The recommended treatment regimen (rifampicin, ethambutol and azithromycin) achieves 65% cure rates but with considerable toxicity and drug-drug interactions [2,3]. Minocycline proved active in monotherapy experiments using the hollow-fibre model [4].
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