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Volume of intraoperative normal saline versus lactated Ringer's solution on acute kidney injury: A secondary analysis of the SOLAR trial.
J Clin Anesth
February 2025
Center for Outcomess Research and Department of Anesthesiology, UTHealth, Houston, TX, United States of America. Electronic address:
Unlabelled: Postoperative acute kidney injury (AKI) is common after non-cardiac surgery. Normal saline and lactated Ringer's solution are both used for volume replacement during surgery. Normal saline decreases renal blood flow and causes hyperchloremic acidosis whereas lactated Ringer's does not.
View Article and Find Full Text PDFThe current (and possible future) role of opioid analgesia in lung cancer surgery.
Best Pract Res Clin Anaesthesiol
March 2024
Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, Department of Anesthesia and Critical Care Medicine, 1275 York Avenue, New York, NY, 10028, USA. Electronic address:
The objectives of this minireview are two-fold. The first is to discuss the evolution of opioid analgesia in perioperative medicine in the context of thoracic non-cardiac surgery. Current standard-of-care, aiming to optimize analgesia and limit undesirable side effects, is discussed in the context of multimodal analgesia, specifically enhanced recovery after thoracic surgery pathways.
View Article and Find Full Text PDFComparative effectiveness of disease modifying antirheumatic drugs for patients with cardiac sarcoidosis.
Rheumatology (Oxford)
December 2024
Medical College of Wisconsin, Milwaukee, WI, USA.
Objectives: We aimed to evaluate the comparative efficacy of disease modifying antirheumatic drugs (DMARDs) for patients with cardiac sarcoidosis.
Methods: We performed a retrospective cohort study of new users of methotrexate, mycophenolate, or azathioprine for sarcoidosis using the US-based TriNetX electronic health records database from 2008-2023. Hazard ratios were calculated using inverse probability of treatment weighted Cox proportional hazards regressions to compare the efficacy of DMARDs with respect to delaying major adverse cardiac events among patients with cardiac sarcoidosis and preventing cardiac sarcoidosis from developing among patients with non-cardiac sarcoidosis.
Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide.
Cell Mol Life Sci
November 2024
School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University of Bristol, University Walk, Bristol, BS8 1TD, UK.
Article Synopsis
- Potassium channels from the human hERG gene are affected by various drugs, and this study specifically investigates the effects of chiral disopyramide, a Class Ia antiarrhythmic, on hERG currents in HEK 293 cells.* -
- The findings show that the S(+) enantiomer of disopyramide is more potent at inhibiting hERG current compared to the R(-) form, with IC values of 3.9 µM and 12.9 µM respectively, and certain mutations in hERG alter these effects.* -
- Molecular simulations indicate that the S(+) form binds more effectively to specific residues in the hERG channel, while the R(-)
Comparison of efficacy and safety of etomidate with other anesthesia induction drugs for patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized controlled trials.
Heliyon
November 2024
Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Article Synopsis
- Etomidate is a widely used anesthetic for cardiac surgery, known for its good cardiovascular safety but its overall efficacy and safety compared to other anesthetics remain unclear.
- This study performed a systematic review of randomized controlled trials to evaluate etomidate's impact on patient outcomes, focusing on factors like mortality rates and hemodynamic measurements in cardiac surgery patients.
- The results showed that etomidate did not significantly change the 30-day mortality rates or other key clinical outcomes compared to other drugs, indicating it may be equally effective as alternative anesthetic options.
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