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Objective: Aim: To showcase a rare retinal lesion and the results of contemporary diagnostic and treatment of interferon-induced retinopathy.
Patients And Methods: Materials and Methods: We describe a case of a 36-year-old patient with interferon-induced retinopathy, with hepatitis C, that received prolonged interferon treatment. Clinical signs, examination and combined laser and pharmacologic treatment were showcased in the study.
High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma.
Hum Mol Genet
April 2024
Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania 7000, Australia.
Article Synopsis
- Primary open angle glaucoma (POAG) is a major global cause of blindness, linked to the degeneration of retinal cells, with raised intraocular pressure (IOP) being a significant risk factor.
- The study involved knocking out 62 genes in human trabecular meshwork cells and used advanced techniques like single-cell RNA sequencing and fluorescence analysis to investigate changes in gene expression and cell morphology.
- Results highlighted key genes (ANGPTL2, LMX1B, CAV1, KREMEN1) affecting POAG, revealing potential genetic networks and cellular changes that could help understand the disease's pathogenesis and explore similar genetic disorders.
Changes in Aqueous Concentrations of Various Cytokines after Intravitreal Bevacizumab Injection for Chronic Central Serous Chorioretinopathy.
Korean J Ophthalmol
December 2023
Department of Ophthalmology, Gachon University Gil Medical Center, Incheon, Korea.
Purpose: This study aimed to investigate changes in cytokine levels after intravitreal bevacizumab injection in patients with chronic central serous chorioretinopathy (CSC).
Methods: In a prospective interventional trial, 12 eyes from 12 patients with chronic CSC and six eyes from six patients who underwent cataract surgery were included as controls. Patients diagnosed as with CSC received a single intravitreal injection of bevacizumab (1.
Anterior chamber cytokine production and postoperative macular edema in patients with diabetes undergoing FLACS.
J Cataract Refract Surg
February 2024
From the Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (Cioana); Uptown Eye Specialists, Vaughan, Ontario, Canada (Cioana, Tong, Chiu, Tam, Somani); Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada (Patodia, Tong, Chiu, Tam, Somani); William Osler Health System, Brampton, Ontario, Canada (Tong, Chiu, Tam, Somani); Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada (Chiu).
Purpose: To evaluate the effect of femtosecond laser-assisted cataract surgery (FLACS) and manual cataract surgery (MCS) on proinflammatory cytokine expression in patients with diabetes vs nondiabetic patients.
Setting: Outpatient surgical center in Vaughan, Ontario, Canada.
Design: Prospective cohort study.
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