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Host Response Protein Biomarkers Indicative of Persistent Acute Kidney Injury in Critically Ill COVID-19 Patients.
Crit Care Explor
March 2025
Center for Experimental and Molecular Medicine, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Importance: Sepsis-related host-response anomalies contribute to acute kidney injury (AKI) duration. Data on the host-response specific to COVID-19-associated AKI (COVID-AKI) in critically ill patients is limited.
Objectives: We postulated that persistent COVID-AKI (> 48 hr) differs in host response from transient (< 48 hr) or no COVID-AKI.
Microfluidic magnetic droplet-based chemiluminescence enzyme immunoassay for multiplex sepsis biomarker screening.
Analyst
March 2025
Department of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, P.R. China.
Sepsis is a systemic inflammatory response syndrome caused by infection, requiring the joint detection of multiplex biomarkers for specific diagnosis. Here, we present a chemiluminescence enzyme immunoassay based on microfluidic magnetic droplets for multiplex sepsis biomarker screening. The droplet-based chemiluminescence enzyme immunoassay (CLIA) technology utilizes multicolor-encoded microspheres to distinguish biomarkers and mesoporous silica-loaded enzymes for signal amplification and catalytic fluorescent substrates.
View Article and Find Full Text PDFChallenge in a Malrotation Case: Presentation Mimicking Severe Combined Immunodeficiency.
J Paediatr Child Health
March 2025
Ihsan Dogramaci Children Hospital, Hacettepe University, Ankara, Turkey.
Objectives: Malrotation is a congenital anomaly characterized by improper positioning of the intestines that can cause a range of symptoms from asymptomatic to life-threatening, including midgut volvulus. Diagnosis of malrotation can be particularly challenging in cases where symptoms resemble those of other illnesses, such as severe combined immunodeficiency (SCID).
Case Report: In this case study, we describe a 2-month-old girl with midgut volvulus secondary to malrotation.
Associations of maternal age with outcomes in very low birth weight singleton infants: a retrospective study.
Front Pediatr
February 2025
Department of Neonatology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Background: With advances in perinatal medicine, there has been a rise in the preterm birth rate, especially the rate of very low birth weight (VLBW) and extremely low birth weight infants. Studies have shown that maternal age during pregnancy and at the time of delivery is associated with pregnancy complications and poor neonatal outcomes. Little is known about the effect of maternal age on the outcome of very low birth weight infants.
View Article and Find Full Text PDFPhase 2 study of chidamide in combination with CAG and venetoclax-azacitidine in older patients with newly diagnosed acute myeloid leukemia.
Front Immunol
March 2025
State Key Laboratory of Experimental Hematology, Senior Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Introduction: Older patients with acute myeloid leukemia (AML) respond poorly to standard induction therapy. DNA methyltransferases (DNMTs) and histone-deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets. However, their effects remains unclear as induction therapy for AML.
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