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Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise.
J Cardiovasc Transl Res
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Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, 226011, China.
HFpEF is a prevalent and complex type of heart failure. The concurrent presence of conditions such as obesity, hypertension, hyperglycemia, and hyperlipidemia significantly increase the risk of developing HFpEF. Mitochondria, often referred to as the powerhouses of the cell, are crucial in maintaining cellular functions, including ATP production, intracellular Ca regulation, reactive oxygen species generation and clearance, and the regulation of apoptosis.
View Article and Find Full Text PDFBackground: Total ankle replacement (TAR) has evolved in the last decade from a procedure rife with complication and failure to a promising alternative to arthrodesis. The ability to maintain ankle joint range of motion is showing great promise in patient-reported outcomes, postsurgical pain, as well as long-term sequalae of joint fusion. Although TAR can be performed via either an anterior or lateral approach both with their own sets of benefits and potential complications, the consensus seems to be that one is no better than the other when performed by high-volume surgeons.
View Article and Find Full Text PDFLeaflet: Operative Steps for Interventional Studies in Neuroscience.
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December 2024
Santa Lucia Foundation, IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.
Background/objectives: Drug development involves multiple stages, spanning from initial discovery to clinical trials. This intricate process entails understanding disease mechanisms, identifying potential drug targets, and evaluating the efficacy and safety of candidate drugs. Clinical trials are designed to assess the effects of drugs on humans, focusing on determining safety profiles, appropriate modes of administration, and comparative efficacy against placebos.
View Article and Find Full Text PDFRetraction Note: Application of big data classification effects based on neural network in video English course and relevant optimization suggestions.
Soft comput
July 2024
Department of International Communication and Culture and Art, Hebei Professional College of Political Science and Law, Shijiazhuang, Hebei 050061 China.
[This retracts the article DOI: 10.1007/s00500-023-08123-x.].
View Article and Find Full Text PDFAnterior Controllable Antedisplacement Fusion (ACAF) in Revision Surgery for Iatrogenic Cervical Kyphosis: Technical Note and Case Series.
Orthop Surg
January 2025
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Background: Iatrogenic cervical kyphosis (ICK) often requires complex anterior and posterior correction, which is associated with multiple complications. Consequently, there is a need to investigate alternative treatment approaches that streamline the operative process and markedly diminish postoperative complications. This study, therefore, aimed to evaluate the feasibility and efficacy of a single-stage anterior controllable antedisplacement fusion (ACAF) in revision surgeries for ICK.
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