AI Article Synopsis
- - The study focuses on small duct primary sclerosing cholangitis (PSC) to understand its natural progression and outcomes over time.
- - A total of 32 patients were analyzed, with a diagnosis taking an average of 69 months and a follow-up period of about 63 months, during which none developed cholangiocarcinoma.
- - Findings indicate that small duct PSC generally has a benign course, as most patients did not progress to large duct PSC, with only a few showing changes after long-term monitoring.
Article Abstract
Background/aims: This study aims at describing the natural history and outcome of small duct primary sclerosing cholangitis (PSC).
Methods: Thirty-two patients with small duct PSC were studied. The average time taken for diagnosis was 69 (1-168) months. The median follow-up time was 63 (1-194) months.
Results: All patients including one who underwent liver transplantation because of end-stage liver disease and hepatocellular carcinoma were alive at follow-up. None developed cholangiocarcinoma. In 27 patients repeated cholangiographic examinations were done after a median time of 72 (12-192) months from first ERCP. Four developed features of large duct PSC.
Conclusions: Small duct PSC rarely progresses to large bile duct PSC and it seems to have a benign course in most patients and no development of cholangiocarcinoma was found.
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| http://dx.doi.org/10.1016/s0168-8278(02)00036-3 | DOI Listing |
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