AI Article Synopsis

  • Patients with metastatic hepatoblastoma typically have a poor prognosis, prompting researchers to explore high-dose chemotherapy with bone marrow rescue as a treatment option.
  • Three patients underwent high-dose chemotherapy, with varying responses including additional surgeries and multiple treatment rounds, ultimately leading to positive outcomes.
  • Although conclusions about the effectiveness of high-dose chemotherapy remain unclear due to the small sample size, there are indications that a multi-faceted treatment approach may enhance survival rates for these patients.

Article Abstract

Background: Despite the advent of effective chemotherapy,a poor prognosis has been reported for patients with metastatic hepatoblastoma. To improve this prognosis, we conducted high-dose chemotherapy with autologous bone marrow rescue in patients with metastatic hepatoblastoma.

Methods And Results: Three patients were treated with high-dose chemotherapy. In patient 1, high-dose chemotherapy was given after the patient's first pulmonary relapse. Additional pulmonary metastases, which developed more than 6 months after high-dose chemotherapy, were treated by multiple thoracotomy without additional chemotherapy. Patient 2 presented additional pulmonary metastases soon after the end of the first thoracotomy and high-dose chemotherapy. Because of a decreased serum alpha-fetoprotein level after re-excision of the pulmonary metastases, a second round of high-dose chemotherapy was performed. In patient 3, multiple pulmonary metasteses responded to preoperative chemotherapy and disappeared according to the chest computed tomography. Intensive treatment with a high-dose chemotherapeutic regimen was performed at the end of postoperative chemotherapy. All three patients are alive and well, more than 6 years after receiving their diagnosis.

Conclusion: The role of high-dose chemotherapy in treatment of metastatic hepatoblastoma could not be clarified,because of the small number of patients. However, the better outcome of our patients indicates that multimodal therapy, including high-dose chemotherapy, may improve the outcome of the patients with metastatic hepatoblastoma.

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Source
http://dx.doi.org/10.1046/j.1442-200x.2002.01549.xDOI Listing

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