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Rational Design of an Epidermal Growth Factor Receptor Vaccine: Immunogenicity and Antitumor Research.
Biomolecules
December 2024
College of Life Sciences, Wuhan University, Wuhan 430072, China.
The epidermal growth factor receptor (EGFR) is frequently overexpressed in a variety of human epithelial tumors, and its aberrant activation plays a pivotal role in promoting tumor growth, invasion, and metastasis. The clinically approved passive EGFR-related therapies have numerous limitations. Seven EGFR-ECD epitope peptides (EG1-7) were selected through bioinformatics epitope prediction tools including NetMHCpan-4.
View Article and Find Full Text PDFMucosal-adapted bacteriophages as a preventive strategy for a lethal Pseudomonas aeruginosa challenge in mice.
Commun Biol
January 2025
The Norwegian College of Fishery Science, Faculty of Biosciences, Fisheries and Economics, UiT-The Arctic University of Norway, Tromsø, Norway.
Pseudomonas aeruginosa is an emergent threat due to the antimicrobial resistance crisis. Bacteriophages (phages) are promising agents for phage therapy approaches against P. aeruginosa.
View Article and Find Full Text PDFClinical analysis of infection in patients with liver cirrhosis in Beijing.
World J Hepatol
December 2024
Center of Liver Diseases Division 3, Beijing Ditan Hospital, Capital Medical University, Peking University Ditan Teaching Hospital, Beijing 100015, China.
Background: The incidence of () infection in patients with cirrhosis has been increasing over recent years, posing certain difficulties in clinical treatment.
Aim: To analyze the clinical features of patients with liver cirrhosis and identify the risk factors to help the early diagnosis and treatment of these diseases.
Methods: Clinical data and laboratory tests were collected from 72 patients with cirrhosis confirmed by secretion or blood culture of infection at Beijing Ditan Hospital, Capital Medical University, between May 2016 and October 2018.
Combining treatments for migraine prophylaxis: the state-of-the-art.
J Headache Pain
December 2024
Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Combination treatments for migraine prophylaxis present a promising approach to addressing the diverse and complex mechanisms underlying migraine. This review explores the potential of combining oral conventional prophylactics, onabotulinumtoxin A, monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway, and small molecule CGRP receptor antagonists (gepants). Among the most promising strategies, dual CGRP inhibition through mAbs and gepants may enhance efficacy by targeting both the CGRP peptide and its receptor, while the combination of onabotulinumtoxin A with CGRP treatments offers synergistic pain relief.
View Article and Find Full Text PDFObstetrical Outcomes in Women With a History of Bladder Augmentation.
Health Sci Rep
December 2024
Department of Pediatric Surgery, New Children's Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland.
Purpose: To evaluate possible problems during pregnancy or delivery in women with pediatric bladder augmentation.
Methods: Eleven of 59 women, who had undergone bladder augmentation in our pediatric hospital during 1990-2019, had given birth in our hospital district afterwards and their obstetrical records were evaluated.
Results: Median age at first delivery was 32 years (range 26-42).
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