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Consideration of the EXiLE test for predicting anaphylaxis after diclofenac etalhyaluronate administration.
J Immunotoxicol
December 2024
Teikyo University, Tokyo, Japan.
Diclofenac etalhyaluronate, an active pharmaceutical ingredient in JOYCLU (JCL), serves as a joint function improvement agent in knee and hip osteoarthritis patients. However, frequent cases of anaphylaxis induced by JCL administration have been reported. Recent clinical research suggests the potential utility of the basophil activation test (BAT) in predicting JCL-induced anaphylaxis.
View Article and Find Full Text PDFThe use of perioperative cephalosporin prophylaxis in patients who have a pre-existing penicillin allergy.
Surgery
January 2025
Department of Internal Medicine, Tampere University Hospital, Wellbeing Services County of Pirkanmaa and Faculty of Medicine and Health Technology, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Background: Studies have shown an association between a reported penicillin allergy and an increased risk of surgical site infection. The risk is due to avoidance of cephalosporins and to the use of alternative classes of antibiotics in surgical prophylaxis. The aim of this study was to examine the safety of using cephalosporins in patients with a penicillin allergy label.
View Article and Find Full Text PDFA study on the clinical manifestations in lepidopterism.
Arch Dermatol Res
January 2025
Department of Dermatology, Venereology and Leprosy, Sree Uthradom Thirunal Academy Of Medical Sciences, Trivandrum, 695028, India.
Background: Exposure to hairs of caterpillars and moths are collectively termed as lepidopterism. Clinical manifestations include cutaneous presentation of localized stinging reaction with wheals or vesiculation, acute urticarial papules and plaques, ophthalmic, oropharyngeal involvement to severe life-threatening anaphylactic reactions with angioedema.
Aims: In this study we have determined the prevalence of various cutaneous, oropharyngeal and ophthalmic manifestations of lepidopterism at a tertiary health care center.
Registries in allergy: Structure, target groups, and key findings of allergy-focused registries in Germany.
Allergol Select
December 2024
Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
In allergology, clinical registries fill knowledge gaps of epidemiology, mechanisms of allergic diseases, and real-world treatment outcomes. Considering the continuous rise of allergic diseases worldwide, registries become increasingly important for the optimization and harmonization of patient care. In the current review, we present four ongoing allergy-focused registries initiated in Germany.
View Article and Find Full Text PDFManagement and disease burden of children and adults with severe IgE-mediated food allergy: Are adults the lost population?
World Allergy Organ J
December 2024
Novartis Pharma GmbH, Nuernberg, Germany.
Background: Lacking causal treatment options in most cases, severe IgE-mediated food allergies (IgE-FA) are associated with a high burden of disease due to permanent risk of anaphylactic reactions after accidental allergen ingestion. To date, only few data comparing health resources and burden of disease between the pediatric and adult population are available.
Objective: Our survey aimed to assess the care situation of pediatric and adult patients with severe, self-reported physician-diagnosed IgE-FA.
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