Fibrosis is one of the hallmarks of inflammatory and repair processes in pathology. Various exogenous and endogenous stimuli, including tumor development, can induce inflammatory reactions. During the post-equilibrium phase after IV injection of non specific contrast media, CT and/or MR allow the study of these inflammatory answers to tumoral or infectious processes. Delayed enhancement of collagenic fibrous tissue during the late post-equilibrium phase is an essential complementary data in the characterization of many liver lesions: cirrhosis, cholangiocarcinoma, focal nodular hyperplasia, fibrous metastasis. but also for the differential diagnosis of pancreatic diseases (groove pancreatitis vs ductal adenocarcinoma) or of gastro-intestinal diseases (gastric adenocarcinoma vs lymphoma, mechanical complication vs inflammatory bouts of ileal Crohn's disease).
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Investigation of oral bioavailability and brain distribution of the Ind(8)-Val conjugate of indinavir in rodents.
J Pharm Pharmacol
April 2005
EA3809 Pharmacologie des Agents Anti-Infectieux, Faculté de Médecine & Pharmacie, 86005 Poitiers Cedex, France.
Protease inhibitors are successfully used for the treatment of acquired immune deficiency syndrome (AIDS) although their biopharmaceutical characteristics are not optimal. Prodrugs have therefore been synthesized to increase protease inhibitor bioavailability and brain distribution. Among several compounds tested, a valine derivative of indinavir (Ind(8)-Val) showed promising characteristics using an in-vitro Caco-2 cell model.
View Article and Find Full Text PDF[Groove pancreatitis. Diagnostic impact of dynamic radiology].
Presse Med
November 2003
Service de pathologie digestive, Hôpital d'instruction des armées Legouest, Metz Armées.
Introduction: Described by Becker in 1973, groove pancreatitis is a rare segmental chronic pancreatitis affecting the groove between the head of the pancreas, the duodenum and the common bile duct. Mimicking pancreatic head carcinoma, surgical exploration is often required.
Observation: Diagnosis of groove pancreatitis was made on computed tomography and MR imaging (groove fibrosis) in a 58 year-old man presenting with acute pancreatitis complicated by bilary and duodenal stenosis, with totally favourable outcome within 5 months with conservative treatment.
Fibrosis is one of the hallmarks of inflammatory and repair processes in pathology. Various exogenous and endogenous stimuli, including tumor development, can induce inflammatory reactions. During the post-equilibrium phase after IV injection of non specific contrast media, CT and/or MR allow the study of these inflammatory answers to tumoral or infectious processes.
View Article and Find Full Text PDFCholangiocarcinoma: delayed CT contrast enhancement patterns.
Radiology
April 1997
Department of Radiology, University of Pittsburgh Medical Center, PA 15213-2582, USA.
Purpose: To determine the usefulness of delayed post-equilibrium-phase contrast material-enhanced images in evaluation of intrahepatic cholangiocarcinoma.
Materials And Methods: Review of surgical, pathologic, and radiologic records revealed 47 patients with proved cholangiocarcinoma with delayed (6-36 minutes) post-equilibrium-phase contrast-enhanced computed tomographic (CT) scans. Unenhanced, dynamic contrast-enhanced, and delayed images were retrospectively reviewed, and enhancement patterns for cholangiocarcinoma lesions were recorded.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!