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[Differential diagnoses of central serous chorioretinopathy : Is that really a central serous chorioretinopathy?].
Ophthalmologie
January 2025
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Deutschland.
The accurate diagnosis of central serous chorioretinopathy (CSC) and its distinction from differential diagnoses is crucial for effective patient counseling and treatment. This is achieved through a targeted patient history and multimodal imaging, which distinguish CSC from other ocular diseases also characterized by subretinal fluid and changes in the retinal pigment epithelium. In this article we identify the key differential diagnoses of CSC and illustrate the characteristic differential diagnostic features of each disease.
View Article and Find Full Text PDF[Stress and other risk factors in central serous chorioretinopathy-A myth?].
Ophthalmologie
January 2025
Department of Ophthalmology, St. Franziskus Hospital, Muenster, Deutschland.
Since the initial description of central serous chorioretinopathy (CSC) by von Graefe in 1866, various risk factors for this condition have been described and discussed. In addition to established factors, such as the use of corticosteroids, psychosomatic factors, particularly stress, have increasingly come into focus in the literature. Studies have shown that psychological stress and emotional stressors not only impair well-being but also trigger physiological responses that could increase the risk of CSC.
View Article and Find Full Text PDF[Implementation and evaluation of a solution for automated documentation of the doctor-patient dialogue (ADAPI) in ophthalmology using the example of the IVI routine].
Ophthalmologie
January 2025
Augenklinik Sulzbach, Knappschaftsklinikum Saar, An der Klinik 10, 66280, Sulzbach/Saar, Deutschland.
Background: The increasing bureaucratic burden in everyday clinical practice impairs doctor-patient communication (DPC). Effective use of digital technologies, such as automated semantic speech recognition (ASR) with automated extraction of diagnostically relevant information can provide a solution.
Objective: The aim was to determine the extent to which ASR in conjunction with semantic information extraction for automated documentation of the doctor-patient dialogue (ADAPI) can be integrated into everyday clinical practice using the IVI routine as an example and whether patient care can be improved through process optimization.
Mass Spectrometry Analysis of Chemically and Collisionally Dissociated Molecular Glue- and PROTAC-Mediated Protein Complexes Informs on Disassembly Pathways.
J Am Soc Mass Spectrom
January 2025
Technical University of Darmstadt, Clemens-Schöpf Institute of Organic Chemistry and Biochemistry, Department of Chemistry, Peter-Grünberg-Straße 4, 64287 Darmstadt, Germany.
Molecular glues (MGs) and proteolysis-targeting chimeras (PROTACs) are used to modulate protein-protein interactions (PPIs), via induced proximity between compounds that have little or no affinity for each other naturally. They promote either reversible inhibition or selective degradation of a target protein, including ones deemed undruggable by traditional therapeutics. Though native MS (nMS) is capable of analyzing multiprotein complexes, the behavior of these artificially induced compounds in the gas phase is still not fully understood, and the number of publications over the past few years is still rather limited.
View Article and Find Full Text PDFConformationally Restricted Macrocycles as Improved FKBP51 Inhibitors Enabled by Systematic Linker Derivatization.
Angew Chem Int Ed Engl
January 2025
Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt Peter-Grünberg Strasse 4, 64287, Darmstadt, Germany.
Article Synopsis
- Macrocycles are seen as effective tools for targeting hard-to-reach proteins inside cells, but improving them from initial linear structures is still a work in progress.
- Researchers studied linker modification to enhance macrocycle properties, focusing on FKBP51 and producing over 140 versions with different linkers.
- They discovered that these modifications led to better affinity, stability, and solubility of the macrocycles compared to earlier models, and emphasized the importance of understanding the 3D shapes of these molecules in drug development.
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