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Differential diagnosis of iron deficiency anemia from aplastic anemia using machine learning and explainable Artificial Intelligence utilizing blood attributes.
Sci Rep
January 2025
L&T Technology Services Limited, Mysore, Karnataka, India.
As per world health organization, Anemia is a most prevalent blood disorder all over the world. Reduced number of Red Blood Cells or decrease in the number of healthy red blood cells is considered as Anemia. This condition also leads to the decrease in the oxygen carrying capacity of the blood.
View Article and Find Full Text PDFDevelopment of amphiphilic self-assembled nucleolipid as BBB targeting probe based on SPECT.
Discov Nano
December 2024
Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, 110054, India.
Several approaches have been utilised to deliver therapeutic nanoparticles inside the brain but rendered by certain limitation such as active efflux, non-stability, toxicity of the nanocarrier, transport, physicochemical properties and many more. In this context use of biocompatible nano carriers is currently investigated. We herein present the hypothesis that the nucleoside-lipid based conjugates (nucleolipids) which are biocompatible in nature and have molecular recognition can be tuned for improved permeation across blood-brain barrier (BBB).
View Article and Find Full Text PDFDynamics of antibody engagement of red blood cells and .
Front Immunol
December 2024
Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Exposure to allogenic red blood cells (RBCs), either through pregnancy or transfusion, can result in alloimmunization, which can lead to severe hemolytic transfusion reactions and pregnancy complications. Passively administered antibodies can be used to prevent alloimmunization, where steric hindrance of allogeneic epitopes has been postulated as one mechanism whereby antibody engagement may prevent RBC alloimmunization. However, the dynamics of antibody engagement on the RBC surface has remained difficult to study.
View Article and Find Full Text PDFCytoadhesion of Plasmodium falciparum-Infected Red Blood Cells Changes the Expression of Cytokine-, Histone- and Antiviral Protein-Encoding Genes in Brain Endothelial Cells.
Mol Microbiol
December 2024
Research Group Host-Parasite Interaction, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Malaria remains a significant global health problem, mainly due to Plasmodium falciparum, which is responsible for most fatal infections. Infected red blood cells (iRBCs) evade spleen clearance by adhering to endothelial cells (ECs), triggering capillary blockage, inflammation, endothelial dysfunction and altered vascular permeability, prompting an endothelial transcriptional response. The iRBC/HBEC-5i model, where iRBCs present IT4var04 (VAR2CSA) on their surface, was used to analyze the effects of iRBC binding on ECs at different temperature (37°C vs.
View Article and Find Full Text PDFImproved Malaria Therapy with Cationic Nanocapsules Demonstrated in -Infected Rodents Using Whole Blood Surrogate Population PK/PD Modeling.
Pharmaceutics
October 2024
Pharmacology and Pharmacometric Laboratory, LABFAR, Federal University of Pampa (UNIPAMPA), Uruguaiana 97501-970, RS, Brazil.
: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided to establish a pharmacokinetic/pharmacodynamic (PK/PD) model of the quinine population in WB using -infected mice, with a subsequent model comparison for nanocapsules coated with polysorbate (NCP80) or prepared with Eudragit RS (NCEUD). The WB quinine population pharmacokinetic model in rats was developed using plasma and partition coefficients for rat erythrocytes.
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